2. Others Membrane Transporter/Ion Channel Neuronal Signaling
  3. Isotope-Labeled Compounds Sodium Channel Calcium Channel
  4. Ranolazine-d8

Ranolazine-d8 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent.

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Ranolazine-d<sub>8</sub> Chemical Structure

Ranolazine-d8 Chemical Structure

CAS No. : 1092804-88-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Ranolazine-d8:

Ranolazine-d8 Related Antibodies

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Description

Ranolazine-d8 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ranolazine-d8 Related Antibodies
Molecular Weight

435.59

Formula

C24H25D8N3O4
CAS No.
Unlabeled CAS

95635-55-5
Appearance

Solid

Color

White to off-white

SMILES

O(CC(CN1C(C(N(CC(NC2=C(C)C=CC=C2C)=O)C(C1([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])O)C3=C(OC)C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (229.57 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2957 mL 11.4787 mL 22.9574 mL
5 mM 0.4591 mL 2.2957 mL 4.5915 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2957 mL 11.4787 mL 22.9574 mL 57.3934 mL
5 mM 0.4591 mL 2.2957 mL 4.5915 mL 11.4787 mL
10 mM 0.2296 mL 1.1479 mL 2.2957 mL 5.7393 mL
15 mM 0.1530 mL 0.7652 mL 1.5305 mL 3.8262 mL
20 mM 0.1148 mL 0.5739 mL 1.1479 mL 2.8697 mL
25 mM 0.0918 mL 0.4591 mL 0.9183 mL 2.2957 mL
30 mM 0.0765 mL 0.3826 mL 0.7652 mL 1.9131 mL
40 mM 0.0574 mL 0.2870 mL 0.5739 mL 1.4348 mL
50 mM 0.0459 mL 0.2296 mL 0.4591 mL 1.1479 mL
60 mM 0.0383 mL 0.1913 mL 0.3826 mL 0.9566 mL
80 mM 0.0287 mL 0.1435 mL 0.2870 mL 0.7174 mL
100 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5739 mL
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Ranolazine-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ranolazine-d81092804-88-0Isotope-Labeled CompoundsSodium ChannelCalcium ChannelNa channelsNa+ channelsCa2+ channelsCa channelsInhibitorinhibitorinhibit

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