RB-005

Cat. No.: HY-12900: FAQs
Data Sheet Handling Instructions

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RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC₅₀=3.6 µM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of SK1 and SK2, which can be used in the study of inflammatory diseases and cancer.

For research use only. We do not sell to patients.

RB-005 Chemical Structure

CAS No. : 1425049-20-2

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SphK1 SphK2

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

SphK1

3.6 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	3.6 μM Compound: RB-005	Inhibition of recombinant sphingosine kinase 1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins in presence of [gamma32P]-ATP Inhibition of recombinant sphingosine kinase 1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins in presence of [gamma32P]-ATP	[PMID: 24164513]
Sf9	IC₅₀	3.6 μM Compound: RB-005	Inhibition of human recombinant SphK1 expressed in Sf9 cells assessed as radiolabeled products using 5 uM sphingosine and 10 uM gamma[32P]ATP by liquid scintillation counting Inhibition of human recombinant SphK1 expressed in Sf9 cells assessed as radiolabeled products using 5 uM sphingosine and 10 uM gamma[32P]ATP by liquid scintillation counting	[PMID: 25643074]

Molecular Weight

317.51

Formula

C₂₁H₃₅NO

CAS No.

1425049-20-2

SMILES

CCCCCCCCC1=CC=C(CCN2CCC(O)CC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Baek D J, et al. Structure–activity relationships and molecular modeling of sphingosine kinase inhibitors[J]. Journal of medicinal chemistry, 2013, 56(22): 9310-9327. [Content Brief]

RB-005 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RB-0051425049-20-2RB005RB 005SphKSphingosine kinaseSK1SK2selective inhibitorcancerinflammationInhibitorinhibitorinhibit

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