ADK/Adenosine Kinase Protein, Human (sf9, His-GST)

ADK is an enzyme that catalyzes the transfer of gamma-phosphate from adenosine triphosphate (ATP) to adenosine (Ado) to form adenosine monophosphate (AMP). ADK acts as a potential regulator of extracellular adenosine and intracellular adenine nucleotide concentrations. ADK is a therapeutic target for controlling obesity and non-alcoholic fatty liver disease. ADK/Adenosine Kinase Protein, Human (sf9, His-GST) is the recombinant human-derived ADK/Adenosine Kinase protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of ADK/Adenosine Kinase Protein, Human (sf9, His-GST) is 345 a.a., with molecular weight of ~60 kDa.

Adenosine kinase is an enzyme that catalyzes the transfer of γ-phosphate from adenosine triphosphate (ATP) to adenosine (Ado) to form adenosine monophosphate (AMP). Catalyze the phosphorylation of purine nucleoside adenosine at the 5 'position in an ATP-dependent manner. ADK acts as a potential regulator of extracellular adenosine and intracellular adenine nucleotide concentrations. ADK promotes excess fat deposition and liver inflammation by inhibiting fatty acid oxidation in hepatocytes and producing hepatocellular proinflammatory mediators, which is a therapeutic target for controlling obesity and non-alcoholic fatty liver disease^[1][2][3].

Human

Sf9 insect cells

N-His;N-GST

AAH03568 (M1-H345)

132  [NCBI]

Approximately 60 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.