BTN1A1 Protein, Human (HEK293, Fc)

BTN1A1 Protein is implicated in milk-fat droplet secretion and may serve as a membrane-associated receptor in lactation processes. Additionally, it exhibits immune-regulatory functions, inhibiting T-cell proliferation and modulating cytokine secretion. BTN1A1's association with xanthine dehydrogenase/oxidase suggests diverse cellular functions, inviting further exploration into its role in various biological pathways. BTN1A1 Protein, Human (HEK293, Fc) is the recombinant human-derived BTN1A1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BTN1A1 Protein, Human (HEK293, Fc) is 216 a.a., with molecular weight of 60-80 kDa.

BTN1A1 Protein is suggested to play a role in the secretion of milk-fat droplets, indicating its potential involvement in the complex processes associated with lactation. Additionally, it may act as a specific membrane-associated receptor facilitating the association of cytoplasmic droplets with the apical plasma membrane, as suggested by similarity analyses. Moreover, BTN1A1 exhibits inhibitory effects on the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, impacting T-cell metabolism, and modulating the secretion of IL2 and IFNG, highlighting its potential role in immune regulation. Notably, BTN1A1 also appears to associate with xanthine dehydrogenase/oxidase, raising further questions about its diverse cellular functions and potential implications in various biological pathways.

Human

HEK293

C-hFc

Q13410 (A27-R242)

696  [NCBI]

APFDVIGPPEPILAVVGEDAELPCRLSPNASAEHLELRWFRKKVSPAVLVHRDGREQEAEQMPEYRGRATLVQDGIAKGRVALRIRGVRVSDDGEYTCFFREDGSYEEALVHLKVAALGSDPHISMQVQENGEICLECTSVGWYPEPQVQWRTSKGEKFPSTSESRNPDEEGLFTVAASVIIRDTSAKNVSCYIQNLLLGQEKKVEISIPASSLPR

60-80 kDa

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.