2. Gene
  3. BTN1A1 - butyrophilin subfamily 1 member A1 Gene

BTN1A1 - butyrophilin subfamily 1 member A1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BT; BTN; BTN1

Gene ID: 696 | Gene type: protein coding

About BTN1A1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,500,303-26,510,425 (from NCBI)

This gene has 2 transcripts (splice variants), 99 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008]

BTN1A1 Products(1)

mRNA Protein Name
NM_001732.3 NP_001723.2 butyrophilin subfamily 1 member A1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTN1A1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (31 - 126)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (152 - 227)

PRY

PRY: SPRY-associated domain (305 - 353)

SPRY

SPRY: SPRY domain (355 - 473)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 526 a.a.
Protein Preferred Names Protein Names

butyrophilin subfamily 1 member A1

bK14H9.2 (butyrophilin, subfamily 1, member A1)

BTN1A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BTN1A1 Q13410 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
BTN1A1 Q13410 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
BTN1A1 Q13410 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
BTN1A1 Q13410 MOSPD2 Homo sapiens Q8NHP6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTN1A1 Proteins

Cat. No. Product Name Accession Purity
HY-P7689 BTN1A1 Protein, Human (HEK293, His) Q13410 (A27-R242) ≥95%
HY-P70060 BTN1A1 Protein, Human (HEK293, Fc) Q13410 (A27-R242) ≥95%
HY-P72343 BTN1A1 Protein, Human (Biotinylated, HEK293, His-Avi) Q13410 (A27-R242) ≥95%
HY-P78395 BTN1A1 Protein, Human (HEK293, His-Avi) Q13410 (A27-R242) ≥95%

Related Diseases

Diseases Alias
Tibial Neuropathy

Posterior Tibial Neuropathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01670 BTN1A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BTN1A1 VGNC VGNC:60207
Rattus norvegicus BTN1A1 RGD RGD:1306984
Macaca mulatta BTN1A1 VGNC VGNC:70290
Bos taurus BTN1A1 VGNC VGNC:107283
Canis familiaris BTN1A1 VGNC VGNC:38562
Mus musculus BTN1A1 MGD MGI:103118
Others BTN1A1 NCBI