C-Reactive Protein, Mouse (HEK293, His)

C-reactive protein (CRP) has cholesterol-binding, complement C1q complex-binding, and low-density lipoprotein particle-binding activities, and plays a role in complement activation, gene expression regulation, and superoxide anion generation. It is located in filopodia and growth cones and is expressed in embryos and liver. C-Reactive Protein, Mouse (HEK293, His) is the recombinant mouse-derived C-Reactive protein, expressed by HEK293 , with C-His labeled tag.

The C-reactive protein (CRP), predicted to possess several functions such as cholesterol binding activity, complement component C1q complex binding activity, and low-density lipoprotein particle binding activity, is anticipated to play a role in diverse processes, including complement activation via the classical pathway, regulation of gene expression, and the regulation of superoxide anion generation. It is predicted to act upstream of vasoconstriction and is expected to be located in filopodia and growth cones, with activity in the extracellular space. This protein is expressed in embryos and the liver. The human ortholog of CRP is implicated in various diseases, including Kawasaki disease, autoimmune diseases, macular degeneration, middle cerebral artery infarction, and nephritis. Notably, CRP exhibits biased expression in tissues such as the liver during embryonic and adult stages.

Mouse

HEK293

C-His

P14847/NP_031794.3 (H20-S225)

12944  [NCBI]

HEDMFKKAFVFPKESDTSYVSLEAESKKPLNTFTVCLHFYTALSTVRSFSVFSYATKKNSNDILIFWNKDKQYTFGVGGAEVRFMVSEIPEAPTHICASWESATGIVEFWIDGKPKVRKSLHKGYTVGPDASIILGQEQDSYGGDFDAKQSLVGDIGDVNMWDFVLSPEQISTVYVGGTLSPNVLNWRALNYKAQGDVFIKPQLWS

25-30 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.