CCR4 Protein, Human (Cell-Free, His)

CCR4 protein-VLP is a multifunctional entity that acts as a high-affinity receptor for CC-type chemokines and specifically binds CCL17/TARC, CCL22/MDC, and CKLF1. It mediates chemotactic responses through G(i) protein and activates the phosphatidylinositol-calcium second messenger system. CCR4 Protein, Human (Cell-Free, His) is the recombinant human-derived CCR4, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CCR4 Protein, Human (Cell-Free, His) is 360 a.a.,

CCR4 Protein-VLP, a versatile entity, stands out as a high-affinity receptor for C-C type chemokines, specifically demonstrating binding affinity for CCL17/TARC, CCL22/MDC, and CKLF isoform 1/CKLF1. Its functional spectrum extends to the mediation of chemotactic responses through G(i) proteins, which activate a phosphatidylinositol-calcium second messenger system. Beyond its role as a chemoattractant homing receptor on circulating memory lymphocytes, CCR4 Protein-VLP also serves as a coreceptor for certain primary HIV-2 isolates. In the central nervous system (CNS), intriguingly, it has the potential to mediate hippocampal-neuron survival, adding a layer of complexity to its multifaceted functions.

Human

E. coli Cell-free

N-10*His

P51679 (M1-L360)

1233

44.9 kDa

Greater than 90 % as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.