CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His)

The CD1D2 protein plays a crucial role as an antigen-presenting molecule, binding self and non-self glycolipids and presenting them to T-cell receptors on natural killer T-cells. In partnership with B2M, it mediates immune responses, and its interactions with MHC II and CD74 highlight its significance in the complex network of immune system regulation. CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived CD1D2-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag.

The CD1D2-B2M heterodimer protein serves as a pivotal antigen-presenting molecule, with the ability to bind both self and non-self glycolipids and subsequently present them to T-cell receptors on natural killer T-cells. In its heterodimeric partnership with B2M (beta-2-microglobulin), CD1D2 plays a crucial role in mediating immune responses. Notably, its interactions with MHC II and CD74 further underscore its significance within the intricate network of immune system regulation.

Immobilized Mouse CD1D2-B2M Heterodimer at 2 μg/mL (100 μL/well) can bind Anti-B2M Antibody. The ED₅₀ for this effect is 0.293 μg/mL.

Mouse

HEK293

C-6*His

P11610 (Q22-G305)&P01887 (I21-M119)

12480  [NCBI]&12010  [NCBI]

Approximately 45-58 & 11-13 kDa.

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.