CD229/SLAMF3 Protein, Mouse (HEK293, His)

The CD229/SLAMF3 protein is an autoligand receptor in the SLAM family that regulates immune cell activation and differentiation through homotypic or heterotypic interactions.These interactions are mediated by cytoplasmic adapters such as SH2D1A/SAP or SH2D1B/EAT-2 and are critical for coordinating innate and adaptive immune responses.CD229/SLAMF3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD229/SLAMF3 protein, expressed by HEK293 , with C-6*His labeled tag.

The CD229/SLAMF3 protein serves as a self-ligand receptor within the signaling lymphocytic activation molecule (SLAM) family, influencing immune cell activation and differentiation through homo- or heterotypic cell-cell interactions. These interactions, regulated by the presence or absence of cytoplasmic adapter proteins such as SH2D1A/SAP and/or SH2D1B/EAT-2, play a crucial role in coordinating both innate and adaptive immune responses. CD229's involvement extends to adhesion reactions between T lymphocytes and accessory cells via homophilic interaction. Additionally, it contributes to T-cell differentiation, promoting a Th17 phenotype with increased IL-17 secretion, a process dependent on the presence of SH2D1A. CD229 also plays a role in maintaining peripheral cell tolerance by acting as a negative regulator of the immune response, potentially disabling autoantibody responses and inhibiting IFN-gamma secretion by CD4(+) T-cells. Moreover, it may negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. Furthermore, CD229 can enhance natural killer (NK) cell activation, and it interacts with SH2D1A, INPP5D, and PTPN11, with the latter interaction being blocked by SH2D1A.

Mouse

HEK293

C-6*His

Q4VBG4 (K48-F454)

17085  [NCBI]

KETPPTVISGMLGGSVTFSLNISKDAEIEHITWNCPPKALALVSYKKDITILDKGYNGRLKVSEDGYSLYMSNLTKSDSGSYYAQINQKNVTLTTNKEFTLHIYEKLQKPQIIVESVTPSDTDSCTFTLICTVKGTKDSVQYSWTREDTHLNTYDGSHTLRVSQSVCDPDLPYTCKAWNPVSQNSSQPVRIWQFCTGASRRKTAAGKTVVGILGEPVTLPLEFRATRATKNVVWVFNTSVISQERRGAATADSRRKPKGSEERRVRTSDQDQSLKISQLKMEDAGPYHAYVCSEASRDPSVRHFTLLVYKRLEKPSVTNSPVHMMNGICKVVLTCSVDGGGNNVTYTWMPLQNKAVMSQGKSHLNVSWESGEHLPNFTCTAHNPVSNSSSQFSSGTICSGPERNKRF

65-75 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.