CD4 Protein, Mouse (Biotinylated, HEK293, His-Avi)

CD4 is a glycoprotein critical in immune responses that binds to interleukin-16 and forms a homodimer. It enhances helper T cell-mediated immune responses and regulates processes such as defense against Gram-negative bacteria and calcium signaling. CD4 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived CD4 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

CD4, a key glycoprotein involved in immune responses, is predicted to perform various functions, including interleukin-16 binding activity, interleukin-16 receptor activity, and protein homodimerization activity. Playing a critical role in helper T cell enhancement of the adaptive immune response, CD4 acts upstream of processes such as the defense response to Gram-negative bacteria, positive regulation of calcium-mediated signaling, and positive regulation of peptidyl-tyrosine phosphorylation. Positioned in the endoplasmic reticulum, on the external side of the plasma membrane, and within membrane rafts, CD4 exhibits biased expression in different tissues, particularly evident in the thymus with an expression level of RPKM 167.0, and the spleen with RPKM 15.0, underscoring its significance in immune function and its potential involvement in immunodeficiency 79.

Mouse

HEK293

C-His;C-Avi

NP_038516.1 (K27-T394)

12504  [NCBI]

KTLVLGKEGESAELPCESSQKKITVFTWKFSDQRKILGQHGKGVLIRGGSPSQFDRFDSKKGAWEKGSFPLIINKLKMEDSQTYICELENRKEEVELWVFKVTFSPGTSLLQGQSLTLTLDSNSKVSNPLTECKHKKGKVVSGSKVLSMSNLRVQDSDFWNCTVTLDQKKNWFGMTLSVLGFQSTAITAYKSEGESAEFSFPLNFAEENGWGELMWKAEKDSFFQPWISFSIKNKEVSVQKSTKDLKLQLKETLPLTLKIPQVSLQFAGSGNLTLTLDKGTLHQEVNLVVMKVAQLNNTLTCEVMGPTSPKMRLTLKQENQEARVSEEQKVVQVVAPETGLWQCLLSEGDKVKMDSRIQVLSRGVNQT

Approximately 52.83 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.