Cd4 - CD4 antigen Gene

Mus musculus

Also known as L3T4; Ly-4

Gene ID: 12504 | Gene type: protein coding

About Cd4

Summary

Predicted to enable several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in helper T cell enhancement of adaptive immune response. Acts upstream of or within several processes, including defense response to Gram-negative bacterium; positive regulation of calcium-mediated signaling; and positive regulation of peptidyl-tyrosine phosphorylation. Located in endoplasmic reticulum; external side of plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd4 Products(1)

mRNA	Protein	Name
NM_013488.3	NP_038516.1	T-cell surface glycoprotein CD4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7486703	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell activation	IDA IDA: Inferred from direct assay	12421911	MGI
acts upstream of calcium-mediated signaling	IDA IDA: Inferred from direct assay	9208839	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	9208839	MGI
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	2784195	MGI
acts upstream of or within cytokine production	IGI IGI: Inferred from genetic interaction	7930593	MGI
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	7930593	MGI
acts upstream of or within defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	14688352	MGI
involved in helper T cell enhancement of adaptive immune response	IMP IMP: Inferred from mutant phenotype	1832488	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9208839	MGI
acts upstream of or within positive regulation of T cell activation	IDA IDA: Inferred from direct assay	12421911	MGI
acts upstream of or within positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	9208839	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9208839	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	8612131	MGI
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	16223484	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	16223484	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7477352	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15128768	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	3262426	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

T-cell surface glycoprotein CD4

T-cell differentiation antigen L3T4

T-cell surface antigen T4/Leu-3

Recombinant Cd4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72904	CD4 Protein, Mouse (HEK293, His)	NP_038516.1 (K27-T394)	≥95%
HY-P77517	CD4 Protein, Mouse (Biotinylated, HEK293, His-Avi)	NP_038516.1 (K27-T394)	≥95%

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0689A	Indinavir sulfate		99.97%	Yes
HY-15440A	Fostemsavir	Inhibitor	99.52%	Unkown
HY-15440B	Fostemsavir Tris	Inhibitor	99.94%	Unkown
HY-B0689	Indinavir		/	Unkown
HY-B0689B	Indinavir sulfate ethanolate		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99222	Teplizumab		≥99.0%	Unkown
HY-P99028	Ibalizumab	Inhibitor	99.52%	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105037A	Forigerimod TFA	Inhibitor	98.89%	Phase 3
HY-148808	Zelasudil	Inhibitor	99.86%	Phase 2
HY-P0272	Peptide T	Inhibitor	98.86%	Phase 2
HY-P0272A	Peptide T TFA	Inhibitor	/	Phase 2
HY-14135	BMS 488043	Inhibitor	/	Phase 2
HY-15440	Temsavir	Inhibitor	98.06%	Phase 1

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99266	Zanolimumab	Inhibitor	99.21%	Phase 3
HY-P9998	Semzuvolimab	Inhibitor	95.00%	Phase 3
HY-P99908	Efineptakin alfa	Activator	/	Phase 2
HY-P99607	Clenoliximab	Inhibitor	/	Phase 2
HY-P99433	Alvircept sudotox	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (68)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150741	ODN 2216		/	Unkown
HY-110382	Cyclic-di-GMP disodium	Activator	99.23%	Unkown
HY-150741C	ODN 2216 sodium	Activator	97.88%	Unkown
HY-107780B	Cyclic-di-GMP diammonium	Activator	99.07%	Unkown
HY-15898	Y-320		99.74%	Unkown
HY-P2560	LCMV GP (61-80)		99.80%	Unkown
HY-134809	Cyclotriazadisulfonamide	Inhibitor	98.54%	Unkown
HY-124750	NecroX-7	Inhibitor	99.69%	Unkown
HY-P1066	Apelin-17(human, bovine)		98.29%	Unkown
HY-155978A	RDN2150 TFA		99.62%	Unkown
HY-119347	Cirsilineol	Inhibitor	≥98.0%	Unkown
HY-P1064	Apelin-36(human)		98.05%	Unkown
HY-139780	JNJ-61803534	Inhibitor	99.88%	Unkown
HY-Y0788	Indoline		99.89%	Unkown
HY-14134	BMS-378806	Inhibitor	98.94%	Unkown
HY-107780	Cyclic-di-GMP	Activator	98.18%	Unkown
HY-157793	SMU-L11		99.64%	Unkown
HY-P1997	Ferrichrome Iron-free		≥98.0%	Unkown
HY-12465	Z-Ile-Leu-aldehyde		97.28%	Unkown
HY-P1065	Apelin-36(rat, mouse)		99.12%	Unkown
HY-W181026	KLF10-IN-1		98.68%	Unkown
HY-164426	HEI3090	Activator	99.04%	Unkown
HY-100039	YYA-021	Inhibitor	98.96%	Unkown
HY-105037	Forigerimod	Inhibitor	/	Unkown
HY-138115	7ß,27-Dihydroxycholesterol	Activator	≥99.0%	Unkown
HY-148432	FGF22-IN-1	Inhibitor	98.07%	Unkown
HY-155978	RDN2150		/	Unkown
HY-76648	NBD-556	Inhibitor	99.57%	Unkown
HY-P1064A	Apelin-36(human) TFA		98.11%	Unkown
HY-16106S	Talazoparib-13C,d4		99.30%	Unkown
HY-W102449S	4-Acetyl-N-methylaniline-13C,d3		97.05%	Unkown
HY-135432	Etrasimod arginine	Modulator	/	Unkown
HY-106055	Murabutide	Inhibitor	/	Unkown
HY-107780A	Cyclic-di-GMP sodium	Activator	/	Unkown
HY-111366	CD12681	Agonist	/	Unkown
HY-119202	(S)-BMS-378806		/	Unkown
HY-121820	DMJ-I-228	Inhibitor	/	Unkown
HY-123312	CK-548	Inhibitor	/	Unkown
HY-123902	Ophiobolin C	Inhibitor	/	Unkown
HY-126037	(±)-ML 209	Antagonist	99.87%	Unkown
HY-137618B	Rp-dGTPαS		/	Unkown
HY-137640A	Sp-8-Br-cAMPS sodium	Agonist	/	Unkown
HY-144746	PD-1/PD-L1-IN-26	Inhibitor	/	Unkown
HY-145491	Resolvin D5		/	Unkown
HY-15091	Anisperimus		/	Unkown
HY-161255	3,4-DAA	Inhibitor	/	Unkown
HY-169335	HIV-1 inhibitor-77	Inhibitor	/	Unkown
HY-B0094S3	Artemisinin-13C,d4		/	Unkown
HY-P10308	[(Cys(Bzl)84,Glu(OBzl)85)]CD4 (81-92)		/	Unkown
HY-P1065A	Apelin-36(rat, mouse) TFA		/	Unkown
HY-P1066A	Apelin-17(human, bovine) TFA		/	Unkown
HY-P1409A	ADWX 1 TFA	Inhibitor	/	Unkown
HY-P2561	Influenza Matrix Protein (61-72)		/	Unkown
HY-P3554	Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl	Inhibitor	/	Unkown
HY-P5930	HOXB7 8–25		/	Unkown
HY-RS02245	CD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W005355S8	Sodium 2-oxobutanoate-13C,d4		/	Unkown
HY-W006057AS14	Sodium 3-methyl-2-oxobutanoate-13C,d4		/	Unkown
HY-Y0781S5	Pyruvic acid-13C,d4		/	Unkown
HY-117160S2	4-trans-Hydroxy glibenclamide-13C,d4		/	Unkown
HY-123756	NBD-10007	Inhibitor	/	Unkown
HY-12926	ST7612AA1		/	Unkown
HY-134809A	Cyclotriazadisulfonamide hydrochloride		/	Unkown
HY-13644	Gusperimus		/	Unkown
HY-154771S	Clopidogrelat-13C,d4		/	Unkown
HY-159123	KHK-6	Inhibitor	/	Unkown
HY-B0202S4	Irbesartan-13C,d4		/	Unkown
HY-110216	5J-4	Inhibitor	95%	Unkown

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99999	Anti-Mouse CD4 Antibody (YTS 191)	Inhibitor	≥95.0%	Unkown
HY-P990792	Anti-Mouse CD4 Antibody (GK1.5)		95.00%	Unkown
HY-P99680	Keliximab	Inhibitor	98.23%	Unkown
HY-P990861	Anti-CD4 Antibody (OKT-4)		/	Unkown
HY-P99790	Priliximab		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd4	NCBI	NCBI:920
Canis familiaris	Cd4	NCBI	NCBI:403931
Macaca fascicularis	Cd4	NCBI	NCBI:101864991
Leporidae	Cd4	NCBI
Rattus norvegicus	Cd4	NCBI	NCBI:24932
Macaca mulatta	Cd4	NCBI	NCBI:713807

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