CLEC12A - C-type lectin domain family 12 member A Gene

Homo sapiens

Also known as CLL1; MICL; CD371; CLL-1; DCAL-2

Gene ID: 160364 | Gene type: protein coding

About CLEC12A

Cytogenetic location: 12p13.31-p13.2 Genomic coordinates (GRCh38): 12:9,951,268-10,006,150 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 23 paralogues. Biased expression in bone marrow (RPKM 14.2), appendix (RPKM 4.4) and 7 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to Other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]

CLEC12A Products(4)

mRNA	Protein	Name
NM_001207010.2	NP_001193939.1	C-type lectin domain family 12 member A isoform 3
NM_001300730.2	NP_001287659.1	C-type lectin domain family 12 member A isoform 4
NM_138337.6	NP_612210.4	C-type lectin domain family 12 member A isoform 1
NM_201623.4	NP_963917.2	C-type lectin domain family 12 member A isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC12A Protein Structure

Lectin_C

0
100
200
265 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 12 member A

C-type lectin protein CLL-1

CLEC12A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLEC12A	Q5QGZ9	CLEC1A	Homo sapiens	Q8NC01	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC12A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76267	CLEC12A/MICL Protein, Human (HEK293, His)	Q5QGZ9-1 (H75-A275)	≥95%
HY-P77631	CLEC12A/MICL Protein, Human (HEK293, Fc)	Q5QGZ9-2 (H65-A265)	≥95%
HY-P77633	CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi)	Q5QGZ9-2 (H65-A265)	≥95%
HY-P77634	CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q5QGZ9-2 (H65-A265)	≥95%
HY-P78653	FITC-Labeled CLEC12A/MICL Protein, Human (HEK293, His, solution)	Q5QGZ9-2 (H65-A265)	≥95%

Related Diseases

Diseases

Alias

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Mixed Phenotype Acute Leukemia, B/Myeloid

Doid:0081038

3mc Syndrome

Craniofacial-Ulnar-Renal Syndrome	Malpuech Facial Clefting Syndrome
Oculopalatoskeletal Syndrome	Carnevale Syndrome
Michels Syndrome	Malpuech-Michels-Mingarelli-Carnevale Syndrome
Carnevale-Krajewska-Fischetto Syndrome	Craniosynostosis With Lid Anomalies
Malpuech Syndrome	Mingarelli Syndrome
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia	Ptosis-Strabismus-Rectus Abdominis Diastasis

Langerhans Cell Histiocytosis

Histiocytosis X	Lch
Langerhans Cell Granulomatosis	Langerhans-Cell Histiocytosis
Letterer-Siwe Disease	Hashimoto-Pritzger Disease
Histiocytosis, Langerhans-Cell	Langerhan'S Cell Histiocytosis
Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes	Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes
Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes	Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb
Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck
Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb	Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Involving Spleen	Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes
Letterer-Siwe Disease Of Intrapelvic Lymph Nodes	Letterer-Siwe Disease Of Intrathoracic Lymph Nodes
Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb	Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb
Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Of Spleen	Familial Letterer-Siwe Disease
Langerhans-Cell Histiocytosis Nos

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99390	Tepoditamab		92.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02781	CLEC12A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CLEC12A	VGNC	VGNC:39325
Bos taurus	CLEC12A	VGNC	VGNC:27423
Mus musculus	CLEC12A	MGD	MGI:3040968
Rattus norvegicus	CLEC12A	RGD	RGD:1592991
Macaca mulatta	CLEC12A	VGNC	VGNC:71377
Felis catus	CLEC12A	VGNC	VGNC:60941
Macaca fascicularis	CLEC12A	NCBI	NCBI:102143884
Others	CLEC12A	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.