CUTC Protein, Human (His)

CUTC proteins potentially regulate copper homeostasis by binding Cu(1+) of each subunit, suggesting a role in the control of cellular copper levels. As a homotetramer, the tetrameric arrangement of CUTC suggests cooperative behavior in managing copper ions. CUTC Protein, Human (His) is the recombinant human-derived CUTC protein, expressed by E. coli , with N-His labeled tag.

The CUTC protein is suggested to potentially play a role in copper homeostasis, indicating its involvement in the regulation of cellular copper levels. Functionally, CUTC can bind one Cu(1+) per subunit, highlighting its ability to interact with copper ions and potentially participate in their transport or storage within the cellular environment. Structurally, CUTC forms a homotetramer, emphasizing its organization as a protein complex consisting of four subunits. The tetrameric arrangement suggests a cooperative mode of action in managing copper ions. The specific mechanisms by which CUTC contributes to copper homeostasis and its role in cellular processes remain areas of interest, underscoring the need for further exploration to elucidate its exact functions and molecular mechanisms.

Human

E. coli

N-6*His

Q9NTM9 (M1-V273)

51076  [NCBI]

MKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERGGADRIELCSGLSEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKADIRLAKLYGADGLVFGALTEDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIKRLIEQAKGRIVVMPGGGITDRNLQRILEGSGATEFHCSARSTRDSGMKFRNSSVAMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV

Approximately 32 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 10% trehalose, 0.02% Tween80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.