CUTC - cutC copper transporter Gene

Homo sapiens

Also known as CGI-32

Gene ID: 51076 | Gene type: protein coding

About CUTC

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:99,732,234-99,756,134 (from NCBI)

This gene has 4 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in testis (RPKM 21.2), fat (RPKM 18.2) and 25 other tissues.

Summary

Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]

CUTC Products(1)

mRNA	Protein	Name
NM_015960.3	NP_057044.2	copper homeostasis protein cutC homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables copper ion binding	IDA IDA: Inferred from direct assay	19878721	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein tetramerization	IPI IPI: Inferred from physical interaction	19878721	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16182249	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16182249	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUTC Protein Structure

CutC

0
100
200
273 a.a.

Protein Preferred Names

Protein Names

copper homeostasis protein cutC homolog

cutC copper transporter homolog

CUTC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CUTC	Q9NTM9	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CUTC	Q9NTM9	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CUTC	Q9NTM9	XPO7	Homo sapiens	Q9UIA9	Anti Tag CoIP	35271311
Intra	CUTC	Q9NTM9	XPO7	Homo sapiens	Q9UIA9	Anti Tag CoIP	29748336
Intra	CUTC	Q9NTM9	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	CUTC	Q9NTM9	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	CUTC	Q9NTM9	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	CUTC	Q9NTM9	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	CUTC	Q9NTM9	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	CUTC	Q9NTM9	SPG21	Homo sapiens	Q9NZD8	Y2H Array	25416956
Intra	CUTC	Q9NTM9	SPG21	Homo sapiens	Q9NZD8	Y2H Array	31515488
Intra	CUTC	Q9NTM9	BCL6	Homo sapiens	P41182	Validated Y2H	25416956
Intra	CUTC	Q9NTM9	BCL6	Homo sapiens	P41182	Y2H Prey Pooling	25416956
Intra	CUTC	Q9NTM9	BCL6	Homo sapiens	P41182	Y2H Array	25416956
Intra	CUTC	Q9NTM9	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	32296183
Intra	CUTC	Q9NTM9	ATXN1	Homo sapiens	P54253	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CUTC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75316	CUTC Protein, Human (His)	Q9NTM9 (M1-V273)	≥95%

Related Diseases

Diseases

Alias

Trimethylaminuria

TMAU	Fish-Odor Syndrome
Fish Malodor Syndrome	Fish Odor Syndrome
Stale Fish Syndrome	Tmauria
Severe Primary Trimethylaminuria	Mesh
D008661	Fish Odour Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03368	CUTC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CUTC	VGNC	VGNC:39737
Mus musculus	CUTC	MGD	MGI:1913638
Macaca mulatta	CUTC	VGNC	VGNC:106028
Bos taurus	CUTC	VGNC	VGNC:27838
Felis catus	CUTC	VGNC	VGNC:61290
Rattus norvegicus	CUTC	RGD	RGD:1304966
Others	CUTC	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.