ELAVL3 Protein, Human (P.pastoris, His)

ELAVL3 protein is an RNA-binding protein that specifically binds to the ARE sequence in target mRNA, including VEGF. It may also interact with polyA tracts through its RRM3. ELAVL3 Protein, Human (P.pastoris, His) is the recombinant human-derived ELAVL3 protein, expressed by P. pastoris , with N-His labeled tag. The total length of ELAVL3 Protein, Human (P.pastoris, His) is 367 a.a., with molecular weight of ~41.5 kDa.

The ELAVL3 protein serves as an RNA-binding protein, specifically binding to AU-rich element (ARE) sequences within target mRNAs, including VEGF mRNA. Additionally, it may interact with poly-A tracts through its third RNA recognition motif (RRM3). ELAVL3 is implicated in potential roles in neuronal differentiation and maintenance, suggesting its involvement in fundamental processes within the nervous system. Furthermore, it plays a role in the stabilization of GAP43 mRNA and contributes to spatial learning. The protein's functional repertoire extends to interaction with MAP1B light chain LC1, further underscoring its involvement in intricate molecular networks associated with RNA regulation and cellular processes related to neuronal functions and learning.

Human

P. pastoris

N-His

Q14576 (M1-A367)

1995  [NCBI]

MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA

Approximately 41.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.