FKBP4 Protein, Human (His)

The FKBP4 protein is an immunophilin with peptidyl prolyl cis-trans isomerase (PPIase) and co-chaperone activity. It plays a key role in the formation of hybrids with steroid receptors, specifically by interacting with heat shock protein 90 (HSP90). FKBP4 Protein, Human (His) is the recombinant human-derived FKBP4 protein, expressed by E. coli , with C-6*His labeled tag. The total length of FKBP4 Protein, Human (His) is 459 a.a., with molecular weight of 50-60 kDa.

FKBP4 Protein, an immunophilin, exhibits both peptidyl-prolyl cis-trans isomerase (PPIase) and co-chaperone activities. It functions as a crucial component within heterocomplexes formed with steroid receptors, interacting notably with heat-shock protein 90 (HSP90). This interaction suggests a potential role in facilitating the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between the cytoplasm and nuclear compartments. Furthermore, FKBP4's isomerase activity influences neuronal growth cones by modulating the opening of TRPC1 channels and serves as a regulator of microtubule dynamics by inhibiting MAPT/TAU's ability to promote microtubule assembly. Additionally, FKBP4 may contribute to mitochondrial protection against oxidative stress.

Human

E. coli

C-6*His

Q02790 (M1-A459)

2288  [NCBI]

MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA

50-60 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.