FKBP4 - FKBP prolyl isomerase 4 Gene

Homo sapiens

Also known as HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase

Gene ID: 2288 | Gene type: protein coding

About FKBP4

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:2,794,970-2,805,423 (from NCBI)

This gene has 8 transcripts (splice variants), 218 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 24.9), kidney (RPKM 21.3) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (HSP90 and HSP70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

FKBP4 Products(1)

mRNA	Protein	Name
NM_002014.4	NP_002005.1	peptidyl-prolyl cis-trans isomerase FKBP4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	9660753	GOA
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	11350175	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11583998	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	11350175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FKBP4 Protein Structure

FKBP_C

TPR_1

TPR_11

0
100
200
300
400
459 a.a.

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase FKBP4

FK506 binding protein 4, 59kDa

Recombinant FKBP4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70405	FKBP4 Protein, Human (His)	Q02790 (M1-A459)	≥95%

Related Diseases

Diseases

Alias

Androgen Insensitivity Syndrome

Androgen Resistance Syndrome	AIS
Testicular Feminization Syndrome	Androgen Receptor Deficiency
Dhtr Deficiency	Dihydrotestosterone Receptor Deficiency
Ar Deficiency	Testicular Feminization
Tfm	Androgen Insensitivity
Androgen-Insensitivity Syndrome	Goldberg-Maxwell Syndrome
Complete Androgen Insensitivity Syndrome	Cais
Feminisation - Testicular	Goldberg - Maxwell Syndrome
Androgen Insensitivity Syndrome, Complete	Morris Syndrome
Ary	AR
Insensitivity Syndrome, Androgen	Androgen Insensitivity Nos

Paralytic Lagophthalmos

Ocular Hypertension

Hypertension, Ocular	Intraocular Pressure Increase
Oh - [Ocular Hypertension]	Oht - [Ocular Hypertension]

Sulfhemoglobinemia

Hypospadias

Hypospadias Familial

Familial Hypospadias

Facial Paralysis

Facial Palsy

Bell Palsy

Facial Nerve Disease

Facial Nerve Disorder	Facial Nerve Diseases
Neuropathy Of Facial Nerve	Disorders Of 7th Cranial Nerve
Disorders Of The Seventh Cranial Nerve

Bell'S Palsy

Bell Palsy	Facial Nerve Palsy
Facial Palsy	Facial Paralysis
Bell'S Palsy	Antoni'S Palsy
Facial Cranial Nerve Paralysis	Idiopathic Facial Palsy
Refrigeration Palsy	Facial Nerve Paralysis
Seventh Cranial Nerve Paralysis	Face Paralysis Nos

Non-Suppurative Otitis Media

Nonsuppurative Otitis Media

Cerebellopontine Angle Tumor

Cerebellopontine Angle Tumour

Neoplasm Of The Cerebellopontine Angle

Schwannoma Of Twelfth Cranial Nerve

Hypoglossal Schwannoma

Schwannoma Of The Twelfth Cranial Nerve

Hypoglossal Nerve Disease

Hypoglossal Nerve Diseases	Disorder Of 12th Nerve
Disorder Of Hypoglossal [12th] Nerve	Disorder Of Hypoglossal Nerve
Disorder Of Xii Nerve	Disorders Of The Twelfth Cranial Nerve
Disorders Of 12th Cranial Nerve

Acoustic Neuroma

Neurofibromatosis Type 2	Vestibular Schwannoma
Acoustic Neurinoma	Bilateral Acoustic Neurofibromatosis
Nf2	Acoustic Neurilemoma
Cerebellopontine Angle Tumor	Neurofibromatosis Central Type
Neurofibromatosis Type Ii	Vestibular Neurilemmoma
Acoustic Tumor	Neurinoma Of The Acoustic Nerve
Acoustic Neurinoma Bilateral	Acoustic Schwannomas Bilateral
Banf	Central Neurofibromatosis
Familial Acoustic Neuromas	Neurofibromatosis 2
Neurofibromatosis Type 2 Merlin	Schwannoma, Acoustic, Bilateral
Neuroma Acoustic	Neuroma, Acoustic
Familial Acoustic Neuroma	Familial Vestibular Schwannoma
Neurofibromatosis, Central Type	Nf2 - [Neurofibromatosis Type 2]

Skin Atrophy

Atrophic Condition Of Skin	Atrophoderma
Atrophy - Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04964	FKBP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FKBP4	RGD	RGD:628729
Mus musculus	FKBP4	MGD	MGI:95543
Macaca mulatta	FKBP4	VGNC	VGNC:72664
Felis catus	FKBP4	VGNC	VGNC:62280
Bos taurus	FKBP4	VGNC	VGNC:29023
Canis familiaris	FKBP4	VGNC	VGNC:40890
Others	FKBP4	NCBI

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