FSTL5 Protein, Human (HEK293, Fc)

FSTL5 is an extracellular matrix-secreted protein. FSTL5 promotes cell proliferation and survival by influencing the Wnt/β-catenin signaling pathway in liver cancer and inhibits the progression of liver cancer by inducing Caspase-dependent apoptosis and regulating Bcl-2 family proteins. FSTL5 Protein, Human (HEK293, Fc) is the recombinant human-derived FSTL5 protein, expressed by HEK293 , with C-hFc labeled tag.

FSTL5 is an extracellular matrix-secreted protein with a molecular structure similar to follicular listatin (FST). Follistatin-like (FSTL) family proteins are involved in cell migration, proliferation, differentiation and organ development. FST can bind to transforming growth factor β (TGF-β) family activating proteins to promote hepatocyte apoptosis and inhibit hepatocyte proliferation. FST can directly bind to TGF-β3 and inhibit EMT in mammary epithelial cells. Down-regulation of FSTL5 promotes cell proliferation and survival by influencing Wnt/β-catenin signaling pathway in liver cancer and inhibits liver cancer progression by inducing Caspase-dependent apoptosis and regulating Bcl-2 family proteins^[1][2][3].

Human

HEK293

C-hFc

Q8N475-1 (R21-A847)

56884  [NCBI]

Approximately 118 kDa.

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.