GBP1 Protein, Human (HEK293, His)

GBP1 Protein belongs to the dynamin superfamily of large GTPases. GBP1 plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. It hydrolyzes GTP to GMP in two consecutive cleavage reactions. GBP1 also acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. In addition, it exhibits antiviral activity against influenza virus. GBP1 Protein, Human (HEK293, His) is the recombinant human-derived GBP1 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of GBP1 Protein, Human (HEK293, His) is 589 a.a., with molecular weight of ~65 kDa.

Guanylate-binding protein 1 (GBP1) belongs to the dynamin superfamily of large GTPases. GBP1 plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. It hydrolyzes GTP to GMP in two consecutive cleavage reactions: GTP is first hydrolyzed to GDP and then to GMP in a processive manner. Following infection, GBP1 is recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and promotes both autophagy and inflammasome assembly. GBP1 also acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. GBP1 confers protection to several pathogens, including the bacterial pathogens L.monocytogenes and M.bovis BCG as well as the protozoan pathogen T.gondii. In addition, it exhibits antiviral activity against influenza virus^[1][2].

Human

HEK293

C-10*His

AAA35871.1 (M1-C589)

2633  [NCBI]

Approximately 65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.