GBP1 - guanylate binding protein 1 Gene

Homo sapiens

Gene ID: 2633 | Gene type: protein coding

About GBP1

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,052,319-89,065,208 (from NCBI)

This gene has 9 transcripts (splice variants), 134 orthologues and 10 paralogues. Broad expression in appendix (RPKM 60.1), lymph node (RPKM 37.4) and 24 other tissues.

Summary

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

GBP1 Products(1)

mRNA	Protein	Name
NM_002053.3	NP_002044.2	guanylate-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein activity	IDA IDA: Inferred from direct assay	7512561	GOA
enables GDP binding	IDA IDA: Inferred from direct assay	10676968	GOA
enables GDP phosphatase activity	IDA IDA: Inferred from direct assay	7512561	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	10676968	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	7512561	GOA
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	24337748	GOA
enables actin binding	IDA IDA: Inferred from direct assay	24337748	GOA
enables cytokine binding	IPI IPI: Inferred from physical interaction	24337748	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	24337748	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16511497	GOA
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	32510692	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21151871	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10676968	GOA
enables spectrin binding	IPI IPI: Inferred from physical interaction	24337748	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	17266443	GOA
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	17266443	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	17266443	GOA
involved in cytolysis in another organism	IDA IDA: Inferred from direct assay	31268602	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	31268602	GOA
involved in defense response to protozoan	IDA IDA: Inferred from direct assay	31268602	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	29144452	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24337748	GOA
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24337748	GOA
involved in negative regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	24337748	GOA
involved in negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	24337748	GOA
involved in negative regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	24337748	GOA
involved in non-canonical inflammasome complex assembly	IDA IDA: Inferred from direct assay	31268602	GOA
involved in positive regulation of pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	31268602	GOA
involved in protein localization to vacuole	IDA IDA: Inferred from direct assay	21151871	GOA
involved in regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	24337748	GOA
involved in regulation of protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	24337748	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17266443	GOA
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	21151871	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17266443	GOA
is active in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	29144452	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24337748	GOA
is active in symbiont cell surface	IDA IDA: Inferred from direct assay	29144452	GOA
is active in vesicle membrane	IDA IDA: Inferred from direct assay	29144452	GOA
located in vesicle membrane	IDA IDA: Inferred from direct assay	21151871	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GBP1 Protein Structure

GBP

GBP_C

0
100
200
300
400
500
592 a.a.

Protein Preferred Names

Protein Names

guanylate-binding protein 1

GBP-1

GBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GBP1	P32455	GBP4	Homo sapiens	Q96PP9	BiFC	21151871
Intra	GBP1	P32455	GBP4	Homo sapiens	Q96PP9	Anti Tag CoIP	21151871
Intra	GBP1	P32455	GBP3	Homo sapiens	Q9H0R5	Anti Tag CoIP	33961781
Intra	GBP1	P32455	GBP3	Homo sapiens	Q9H0R5	Anti Tag CoIP	28514442
Intra	GBP1	P32455	GBP3	Homo sapiens	Q9H0R5	BiFC	21151871
Intra	GBP1	P32455	GBP3	Homo sapiens	Q9H0R5	Anti Tag CoIP	21151871
Intra	GBP1	P32455	GBP1	Homo sapiens	P32455	GMS	16511497
Intra	GBP1	P32455	GBP1	Homo sapiens	P32455	Crosslink	22607347
Intra	GBP1	P32455	GBP1	Homo sapiens	P32455	Anti Tag CoIP	21151871
Intra	GBP1	P32455	GBP2	Homo sapiens	P32456	Anti Tag CoIP	21151871
Intra	GBP1	P32455	GBP1	Homo sapiens	P32455	BiFC	21151871
Intra	GBP1	P32455	GBP1	Homo sapiens	P32455	Y2H	21151871
Intra	GBP1	P32455	GBP2	Homo sapiens	P32456	Anti Tag CoIP	33961781
Intra	GBP1	P32455	GBP1	Homo sapiens	P32455	GMS	22059445
Intra	GBP1	P32455	GBP1	Homo sapiens	P32455	Y2H	22607347
Intra	GBP1	P32455	GBP2	Homo sapiens	P32456	BiFC	21151871
Intra	GBP1	P32455	GBP2	Homo sapiens	P32456	Anti Tag CoIP	28514442
Intra	GBP1	P32455	GBP1	Homo sapiens	P32455	GMS	22607347
Intra	GBP1	P32455	GBP1	Homo sapiens	P32455	X-Ray Diffraction	16511497
Intra	GBP1	P32455	GBP5	Homo sapiens	Q96PP8	Anti Tag CoIP	33961781
Intra	GBP1	P32455	GBP5	Homo sapiens	Q96PP8	BiFC	21151871
Intra	GBP1	P32455	GBP5	Homo sapiens	Q96PP8	Anti Tag CoIP	21151871

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GBP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75172	GBP1 Protein, Human (HEK293, His)	AAA35871.1 (M1-C589)	≥95%

Related Diseases

Diseases

Alias

Pseudopseudohypoparathyroidism

PPHP	Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance
Normocalcemic Pseudohypoparathyroidism	Aho-Pphp Syndrome
Albright Hereditary Osteodystrophy-Pphp Syndrome	Pseudohypoparathyroidism

Ulceroglandular Tularemia

Congenital Toxoplasmosis

Toxoplasmosis, Congenital	Mother-To-Child Transmission Of Toxoplasmosis
Toxoplasma Embryofetopathy	Toxoplasma Embryopathy
Toxoplasmosis - Congen.	Toxoplasmosis Congenital

Central Nervous System Tuberculosis

Intracranial Tuberculoma	Tuberculoma Of Brain
Tuberculosis Of Meninges And Central Nervous System	Tuberculous Abscess Of Brain
Tuberculoma, Intracranial	Tuberculosis, Central Nervous System

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12929	NSC756093	Inhibitor	99.86%	Unkown
HY-RS05307	GBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GBP1	RGD	RGD:1311877
Others	GBP1	NCBI

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