GBP1 - guanylate binding protein 1 Gene

Homo sapiens

Gene ID: 2633 | Gene type: protein coding

About GBP1

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,052,319-89,065,208 (from NCBI)

This gene has 9 transcripts (splice variants), 134 orthologues and 10 paralogues. Broad expression in appendix (RPKM 60.1), lymph node (RPKM 37.4) and 24 other tissues.

Summary

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

GBP1 Products(1)

mRNA	Protein	Name
NM_002053.3	NP_002044.2	guanylate-binding protein 1

GBP1 Protein Structure

GBP

GBP_C

0
100
200
300
400
500
592 a.a.

Protein Preferred Names

Protein Names

guanylate-binding protein 1

GBP-1

Recombinant GBP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75172	GBP1 Protein, Human (HEK293, His)	AAA35871.1 (M1-C589)	≥95%

Related Diseases

Diseases

Alias

Pseudopseudohypoparathyroidism

PPHP	Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance
Normocalcemic Pseudohypoparathyroidism	Aho-Pphp Syndrome
Albright Hereditary Osteodystrophy-Pphp Syndrome	Pseudohypoparathyroidism

Ulceroglandular Tularemia

Congenital Toxoplasmosis

Toxoplasmosis, Congenital	Mother-To-Child Transmission Of Toxoplasmosis
Toxoplasma Embryofetopathy	Toxoplasma Embryopathy
Toxoplasmosis - Congen.	Toxoplasmosis Congenital

Central Nervous System Tuberculosis

Intracranial Tuberculoma	Tuberculoma Of Brain
Tuberculosis Of Meninges And Central Nervous System	Tuberculous Abscess Of Brain
Tuberculoma, Intracranial	Tuberculosis, Central Nervous System

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12929	NSC756093	Inhibitor	99.86%	Unkown
HY-RS05307	GBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GBP1	RGD	RGD:1311877
Others	GBP1	NCBI

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