Haptoglobin Protein, Rat (HEK293, His)

Haptoglobin is a positive regulator of collagen fibril production and may play a crucial role in extracellular matrix organization and remodeling.Its involvement extends to actively regulating MAP kinase activity, helping to increase adipocyte proliferation and reduce differentiation.Haptoglobin Protein, Rat (HEK293, His) is the recombinant rat-derived Haptoglobin protein, expressed by HEK293 , with C-His labeled tag.

ACLP, functioning as a positive regulator of collagen fibrillogenesis, likely plays a crucial role in the organization and remodeling of the extracellular matrix. Its involvement extends to positively regulating MAP-kinase activity in adipocytes, contributing to increased adipocyte proliferation and diminished adipocyte differentiation. Furthermore, ACLP may serve as a positive regulator of NF-kappa-B activity in macrophages, facilitating the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), ultimately enhancing macrophage inflammatory responsiveness. Additionally, ACLP exhibits transcriptional repressor activity, suggesting its involvement in the modulation of gene expression.

Rat

HEK293

C-His

P06866 (M1-N347)

24464  [NCBI]

Approximately 38.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.