HCDH Protein, Mouse (His-SUMO)

HCDH Protein, pivotal in mitochondrial fatty acid beta-oxidation, manages the third step for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Beyond lipid metabolism, HCDH regulates insulin secretion by inhibiting glutamate dehydrogenase 1 (GLUD1) activation, a key enzyme in amino acid-induced insulin secretion. HCDH emerges as a pivotal factor in regulating cellular processes related to energy metabolism and glucose homeostasis. HCDH Protein, Mouse (His-SUMO) is the recombinant mouse-derived HCDH protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HCDH protein, a key participant in mitochondrial fatty acid beta-oxidation, orchestrates the third step of the beta-oxidation cycle specifically for medium and short-chain 3-hydroxy fatty acyl-CoAs ranging from C4 to C10. Beyond its role in lipid metabolism, HCDH exerts regulatory control over insulin secretion by impeding the activation of glutamate dehydrogenase 1 (GLUD1). This inhibition of GLUD1, a crucial enzyme in amino acid-induced insulin secretion, positions HCDH as a pivotal factor in the intricate regulation of cellular processes associated with energy metabolism and glucose homeostasis.

Mouse

E. coli

N-His;N-SUMO

Q61425 (S13-K314)

15107  [NCBI]

SSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAGDEFVEKTLSCLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK

Approximately 49.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.