ICAM-1/CD54 Protein, Mouse (HEK293, His-Fc)

ICAM-1/CD54 protein is a key player in cellular interactions, acting as a ligand for LFA-1. It facilitates endothelial cup assembly during leukocyte migration and regulates immune responses. ICAM-1 also interacts with MUC1, promoting cell aggregation, and participates in immunological synapse formation between antigen-presenting cells and T cells. These interactions showcase ICAM-1's diverse role in cellular adhesion and immune modulation. ICAM-1/CD54 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of ICAM-1/CD54 Protein, Mouse (HEK293, His-Fc) is 458 a.a., with molecular weight of 120-130 kDa.

ICAM-1/CD54 protein emerges as a pivotal component in mediating cellular interactions, serving as a ligand for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Notably, during the trans-endothelial migration of leukocytes, ICAM-1 engagement plays a crucial role in facilitating the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. This intricate molecular process, resembling other members of the ICAM family, underscores ICAM-1's involvement in regulating immune responses and inflammatory reactions. Beyond its role in leukocyte adhesion, ICAM-1 functions as a homodimer and interacts with MUC1, promoting cell aggregation in epithelial cells. Additionally, ICAM-1 establishes interactions with ARHGEF26/SGEF and associates with CD81, CD247, and CD9 on the T cell side, contributing to the formation of immunological synapses between antigen-presenting cells and T cells. These multifaceted interactions highlight the diverse functions of ICAM-1 in cellular adhesion and immune modulation.

Mouse

HEK293

C-hFc;C-His

P13597 (Q28-N485)

15894  [NCBI]

120-130 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.