ICOS Protein, Rhesus Macaque (Biotinylated, HEK293, Fc-Avi)

ICOS proteins play a critical role in enhancing all basic T cell responses to foreign antigens. It promotes cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promotes effective B cell antibody secretion. ICOS Protein, Rhesus Macaque (Biotinylated, HEK293, Fc-Avi) is the recombinant Rhesus Macaque-derived ICOS protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

The ICOS protein plays a crucial role in enhancing all fundamental T-cell responses to foreign antigens, including promoting cell proliferation, secretion of lymphokines, up-regulation of molecules involved in cell-cell interaction, and facilitating effective help for antibody secretion by B-cells. It is indispensable for facilitating efficient communication between T and B-cells, as well as for normal antibody responses to T-cell dependent antigens. Although it does not increase the production of interleukin-2, it has the ability to superinduce the synthesis of interleukin-10. Additionally, ICOS prevents the apoptosis of pre-activated T-cells and plays a critical role in CD40-mediated class switching of immunoglobulin isotypes. It exists as a homodimer connected by disulfide bonds.

Rhesus Macaque

HEK293

C-Avi;C-hFc

H9Z062/NP_001253918.1 (G20-K140)

705788  [NCBI]

Approximately 42.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.