2. Recombinant Proteins
  3. Immune Checkpoint Proteins CD Antigens
  4. Stimulatory Immune Checkpoint Molecules T Cell CD Proteins
  5. ICOS/CD278

ICOS/CD278

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Inducible co-stimulator (ICOS), a member of the CD28/CTLA-4 immunoglobulin superfamily, is a specific T cell co-stimulatory molecule which activates T cells upon binding to its ligand (ICOS-L). It is present on the T cell surface as a disulfide bond-linke

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Cat. No. Product Name / Synonyms Species Source
  • HY-P78673
    ICOS Protein, Mouse (C137S, C138S, HEK293, Fc)

    ICOS; CD278; AILIM; Inducible T-cell costimulator

    		Mouse HEK293
    ICOS protein optimizes essential T-cell responses to foreign antigens, fostering proliferation, lymphokine secretion, up-regulation of cell-cell interaction molecules, and effective B-cell antibody secretion. Crucial for efficient T and B-cell communication, ICOS is vital for normal antibody responses to T-cell dependent antigens. While it doesn't increase interleukin-2 production, it superinduces interleukin-10 synthesis. Moreover, ICOS prevents apoptosis in pre-activated T-cells and plays a critical role in CD40-mediated immunoglobulin class switching. It exists as a homodimer connected by disulfide bonds. ICOS Protein, Mouse (C137S, C138S, HEK293, Fc) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag and C137S, C138S mutation. The total length of ICOS Protein, Mouse (C137S, C138S, HEK293, Fc) is 124 a.a., with molecular weight of 40-52 kDa.
  • HY-P72618
    ICOS Protein, Human (121a.a, HEK293, Fc)

    Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS

    		Human HEK293
    ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (121a.a, HEK293, Fc) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P72619
    ICOS Protein, Mouse (HEK293, His)

    Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS

    		Mouse HEK293
    ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (HEK293, His) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ICOS Protein, Mouse (HEK293, His) is 122 a.a., with molecular weight of 16-30 kDa.
  • HY-P74868
    ICOS Protein, Rat (HEK293, Fc)

    Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS

    		Rat HEK293
    ICOS is a key protein for T cell function and can significantly enhance various T cell responses to foreign antigens. It plays a crucial role in promoting T cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promoting efficient secretion of B cell antibodies. ICOS Protein, Rat (HEK293, Fc) is the recombinant rat-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P76396
    ICOS Protein, Human (HEK293, His-Fc)

    Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS

    		Human HEK293
    ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (HEK293, His-Fc) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
  • HY-P78307
    ICOS Protein, Mouse (124a.a, HEK293, Fc)

    AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850

    		Mouse HEK293
    ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (124a.a, HEK293, Fc) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ICOS Protein, Mouse (124a.a, HEK293, Fc) is 124 a.a., with molecular weight of 65-80 kDa.
  • HY-P78546
    ICOS Protein, Human (C136S, C137S, HEK293, His)

    AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850

    		Human HEK293
    ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (C136S, C137S, HEK293, His) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P76397
    ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi)

    Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS

    		Mouse HEK293
    ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is 142 a.a., with molecular weight of ~42.4 KDa.
  • HY-P78306
    ICOS Protein, Mouse (C137S, C138S, HEK293, His)

    AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850

    		Mouse HEK293
    ICOS protein optimizes essential T-cell responses to foreign antigens, fostering proliferation, lymphokine secretion, up-regulation of cell-cell interaction molecules, and effective B-cell antibody secretion. Crucial for efficient T and B-cell communication, ICOS is vital for normal antibody responses to T-cell dependent antigens. While it doesn't increase interleukin-2 production, it superinduces interleukin-10 synthesis. Moreover, ICOS prevents apoptosis in pre-activated T-cells and plays a critical role in CD40-mediated immunoglobulin class switching. It exists as a homodimer connected by disulfide bonds. ICOS Protein, Mouse (C137S, C138S, HEK293, His) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-His labeled tag and C137S, C138S mutation. The total length of ICOS Protein, Mouse (C137S, C138S, HEK293, His) is 124 a.a., with molecular weight of 27-38 kDa.
  • HY-P70187
    ICOS Protein, Rhesus macaque (HEK293,Fc)

    rRhInducible T-cell costimulator/ICOS, Fc ; Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; CD278; AILIM; CVID1; ICOS

    		Rhesus Macaque HEK293
    ICOS proteins play a critical role in enhancing all basic T cell responses to foreign antigens. It promotes cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promotes effective B cell antibody secretion. ICOS Protein, Rhesus macaque (HEK293,Fc) is the recombinant Rhesus Macaque-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ICOS Protein, Rhesus macaque (HEK293,Fc) is 121 a.a., with molecular weight of 50-60 kDa.
  • HY-P75819
    ICOS Protein, Rhesus Macaque (Biotinylated, HEK293, Fc-Avi)

    Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS

    		Rhesus Macaque HEK293
    ICOS proteins play a critical role in enhancing all basic T cell responses to foreign antigens. It promotes cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promotes effective B cell antibody secretion. ICOS Protein, Rhesus Macaque (Biotinylated, HEK293, Fc-Avi) is the recombinant Rhesus Macaque-derived ICOS protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.
Cat. No. Product Name Effect Purity