IL-33 Protein, Cynomolgus (HEK293, His)

IL-33 Protein, part of the IL-1 family, is a divergent cytokine pivotal in immune responses and inflammation. Operating through its receptor ST2, IL-33 promotes activation and recruitment of immune cells like Th2 cells, mast cells, and eosinophils to inflammation sites. Produced by epithelial and endothelial cells, IL-33 induces pro-inflammatory cytokines and chemokines. Implicated in asthma, allergic diseases, and autoimmune disorders, IL-33 emerges as a therapeutic target for immune response modulation. IL-33 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-33 protein, expressed by HEK293, with N-His labeled tag. The total length of IL-33 Protein, Cynomolgus (HEK293, His) is 162 a.a., with molecular weight of 25-30 kDa.

IL-33 protein belongs to the IL-1 family and is known for its high divergence from other family members. It functions as an important cytokine involved in various immune responses and inflammatory processes. IL-33 plays a crucial role in promoting the activation and recruitment of immune cells, such as T-helper 2 (Th2) cells, mast cells, and eosinophils, to sites of inflammation. It is primarily produced by epithelial and endothelial cells and acts through its receptor, ST2, to induce the production of other pro-inflammatory cytokines and chemokines. IL-33 has been implicated in various diseases, including asthma, allergic diseases, and autoimmune disorders, highlighting its significance as a therapeutic target for modulating immune responses.

Cynomolgus

HEK293

N-His

A0A2K5W3I1 (H109-I270)

102140695  [NCBI]

25-30 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.