JOSD2 Protein, Human

The JOSD2 protein serves as an enzymatic entity capable of cleaving "Lys-63"-linked polyubiquitin chains and, to a lesser extent, "Lys-48"-linked polyubiquitin chains in vitro. This suggests its potential role as a deubiquitinating enzyme involved in the removal of specific ubiquitin linkages. JOSD2 Protein, Human is the recombinant human-derived JOSD2 protein, expressed by E. coli , with tag free. The total length of JOSD2 Protein, Human is 187 a.a., .

JOSD2 (Josephin-2) protein functions as a deubiquitinating enzyme, exhibiting cleavage activity on 'Lys-63'-linked poly-ubiquitin chains with high efficiency and, to a lesser extent, on 'Lys-48'-linked poly-ubiquitin chains in vitro. The enzyme's ability to specifically target and cleave these distinct poly-ubiquitin linkages suggests its involvement in regulating various cellular processes, including protein degradation and signaling pathways mediated by ubiquitination. While further research is needed to elucidate its specific physiological roles, the identified deubiquitinating activity positions JOSD2 as a potential key player in modulating ubiquitin-dependent cellular mechanisms (

Human

E. coli

Tag Free

Q8TAC2 (S2-D188)

126119

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.