METRNL/Meteorin-like Protein, Human (His-SUMO)

METRNL/meteorin-like protein is caused by hormonal changes caused by exercise or cold exposure, which increases energy expenditure. After exercise, it is expressed in skeletal muscle, whereas during cold exposure, it is expressed in adipose tissue. METRNL/Meteorin-like Protein, Human (His-SUMO) is the recombinant human-derived METRNL/Meteorin-like protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

METRNL/Meteorin-like protein is induced in response to hormonal changes triggered by exercise or exposure to cold, contributing to enhanced energy expenditure. Its expression is observed in skeletal muscle post-exercise and adipose tissue during cold exposure, and it circulates in the bloodstream. METRNL/Meteorin-like protein facilitates energy expenditure by promoting the browning of white fat depots and improving glucose tolerance. Interestingly, its thermogenic effects are not directly exerted on adipocytes but involve the stimulation of various immune cell subtypes. It induces an eosinophil-dependent increase in IL4 expression and facilitates the alternative activation of adipose tissue macrophages, crucial for the enhanced expression of thermogenic and anti-inflammatory gene programs in fat. METRNL/Meteorin-like protein is essential for certain cold-induced thermogenic responses, highlighting its role in metabolic adaptations to low temperatures.

Human

E. coli

N-SUMO;N-6*His

Q641Q3-1 (Q46-D311)

284207  [NCBI]

QYSSDRCSWKGSGLTHEAHRKEVEQVYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGRVQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGSIQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEARLGCAPRFKDFQRMYRDAQERGLNPCEVGTD

Approximately 46.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.