MICA Protein, Human (HEK293, mFc)

MICA is the gene for major histocompatibility complex class I chain-associated protein A, encoding a highly polymorphic cell surface protein. Unlike traditional class I molecules, it lacks beta-2-microglobulin association. MICA Protein, Human (HEK293, mFc) is the recombinant human-derived MICA protein, expressed by HEK293 , with N-mFc labeled tag. The total length of MICA Protein, Human (HEK293, mFc) is 96 a.a., with molecular weight of 50-65 kDa.

MICA, the gene encoding the major histocompatibility complex class I chain-related protein A, produces a highly polymorphic protein expressed on the cell surface. Unlike conventional class I molecules, it does not appear to associate with beta-2-microglobulin. Functioning as a ligand for the NKG2-D type II integral membrane protein receptor, this protein acts as a stress-induced antigen recognized by intestinal epithelial gamma delta T cells. Genetic variations in MICA have been linked to susceptibility to psoriasis 1 and psoriatic arthritis. The shedding of MICA-related antibodies and ligands is implicated in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene yields multiple transcript variants. MICA demonstrates ubiquitous expression, with notable levels observed in the lung (RPKM 8.7), endometrium (RPKM 7.4), and 25 other tissues.

Human

HEK293

N-mFc

NP_001276081.1 (R105-S200)

100507436  [NCBI]

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.