2. Gene
  3. MICA - MHC class I polypeptide-related sequence A Gene

MICA - MHC class I polypeptide-related sequence A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MIC-A; PERB11.1

Gene ID: 100507436 | Gene type: protein coding

About MICA

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,400,711-31,415,315 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 407 orthologues and 22 paralogues. Ubiquitous expression in lung (RPKM 8.7), endometrium (RPKM 7.4) and 25 other tissues.

Summary

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related Antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

MICA Products(5)

mRNA Protein Name
NM_000247.3 NP_000238.1 MHC class I polypeptide-related sequence A isoform 1 (MICA*001) precursor
NM_001177519.3 NP_001170990.1 MHC class I polypeptide-related sequence A isoform 2 (MICA*00801) precursor
NM_001289152.2 NP_001276081.1 MHC class I polypeptide-related sequence A isoform 3 (MICA*00801)
NM_001289153.2 NP_001276082.1 MHC class I polypeptide-related sequence A isoform 3 (MICA*00801)
NM_001289154.2 NP_001276083.1 MHC class I polypeptide-related sequence A isoform 4 (MICA*00801)
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
NOT enables beta-2-microglobulin binding IDA
IDA: Inferred from direct assay
8901601 GOA
enables natural killer cell lectin-like receptor binding IDA
IDA: Inferred from direct assay
11491531 GOA
enables natural killer cell lectin-like receptor binding IPI
IPI: Inferred from physical interaction
10426993 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11323699 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
11777960 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
15995699 GOA
involved in T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
10426993 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
11485740 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
11224526 GOA
involved in gamma-delta T cell activation IDA
IDA: Inferred from direct assay
9497295 GOA
involved in immune response to tumor cell IDA
IDA: Inferred from direct assay
10359807 GOA
involved in natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
10426993 GOA
involved in negative regulation of natural killer cell activation IDA
IDA: Inferred from direct assay
20068167 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
20068167 GOA
involved in response to heat IDA
IDA: Inferred from direct assay
8901601 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
8901601 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
18676862 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
10363723 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18676862 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MHC class I polypeptide-related sequence A

HLA class I antigen

MICA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MICA Q29983 LGALS3 Homo sapiens P17931
Crosslink
21712812
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MICA Proteins

Cat. No. Product Name Accession Purity
HY-P70157 MICA Protein, Human (HEK293, His) AAH16929.1 (E24-Q308) ≥95%
HY-P70579 MICA Protein, Human (HEK293, Fc) AAH16929.1 (E24-Q308) ≥95%
HY-P77997 MICA Protein, Human (HEK293, His-Avi) Q96QC4 (E24-Q308) ≥95%
HY-P77998 MICA Protein, Human (Biotinylated, HEK293, His-Avi) Q96QC4 (E24-Q308) ≥95%
HY-P700790 MICA Protein, Human (HEK293, mFc) NP_001276081.1 (R105-S200) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101780A Tinostamustine hydrochloride Inhibitor / Unkown
HY-155311 NKG2D-IN-1 / Unkown
HY-155312 NKG2D-IN-2 / Unkown
HY-RS08424 MICA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-151782 H-(Gly)3-Lys(N3)-OH / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MICA RGD RGD:1311714
Macaca fascicularis MICA NCBI
Mus musculus MICA NCBI