2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Neuregulins
  6. Neuregulin-1 (NRG1)
  7. NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc)

NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc)

Cat. No.: HY-P73330
Handling Instructions

HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) is 71 a.a., with molecular weight of ~38 kDa.

For research use only. We do not sell to patients.

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Description

HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) is 71 a.a., with molecular weight of ~38 kDa.
Background

HRG1-β1 activates HER2/HER3 signaling and up-regulate Fn14 gene expression in parental MCF7 cells. HRG1-β1-mediated Fn14 up-regulation in MCF7/HER2-18 cells is required for maximal MMP-9 production.
Species

Human
Source

HEK293
Tag

N-hFc
Accession

Q02297-6 (T176-K246)
Gene ID
Molecular Construction
N-term
hFc
NRG1-beta 1 (T176-K246)
Accession # Q02297-6
C-term
Synonyms
Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF
Molecular Weight

Approximately 38 kDa
Purity

Greater than 86% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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