NRG1 - neuregulin 1 Gene

Homo sapiens (human)

Also known as GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2

Gene ID: 3084 | Gene type: protein coding

About NRG1

Summary

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as Cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]

NRG1 Products(1)

mRNA	Protein	Name
XM_054360388.1	XP_054216363.1	pro-neuregulin-1, membrane-bound isoform isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ErbB-3 class receptor binding	IDA IDA: Inferred from direct assay	7556068	GOA
enables ErbB-3 class receptor binding	IPI IPI: Inferred from physical interaction	11389077	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	11389077	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	20682778	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7592681	GOA
enables protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	7556068	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	8702723	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	7514177	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	15073182	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB signaling pathway	IDA IDA: Inferred from direct assay	11389077	GOA
involved in ERBB signaling pathway	IMP IMP: Inferred from mutant phenotype	20682778	GOA
involved in ERBB2-ERBB3 signaling pathway	IDA IDA: Inferred from direct assay	8702723	GOA
involved in ERBB2-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	19632177	GOA
involved in ERBB3 signaling pathway	IDA IDA: Inferred from direct assay	27353365	GOA
involved in ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	15219672	GOA
involved in ERBB4-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	8702723	GOA
involved in activation of protein kinase B activity	IMP IMP: Inferred from mutant phenotype	20682778	GOA
involved in activation of transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9553078	GOA
involved in cardiac muscle cell myoblast differentiation	IDA IDA: Inferred from direct assay	17336907	GOA
involved in cell population proliferation	IDA IDA: Inferred from direct assay	11389077	GOA
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	7514177	GOA
involved in endocardial cell differentiation	IDA IDA: Inferred from direct assay	17336907	GOA
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15073182	GOA
involved in negative regulation of cardiac muscle cell apoptotic process	IDA IDA: Inferred from direct assay	9553078	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	9553078	GOA
involved in negative regulation of secretion	IDA IDA: Inferred from direct assay	10559227	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20682778	GOA
involved in positive regulation of cardiac muscle cell proliferation	IDA IDA: Inferred from direct assay	9553078	GOA
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	7556068	GOA
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	9553078	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20682778	GOA
involved in positive regulation of peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	15219672	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	10559227	GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	16221846	GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	16221846	GOA
involved in sequestering of metal ion	EXP EXP: Inferred from Experiment	25944317	GOA
involved in ventricular cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	9553078	GOA
involved in ventricular trabecula myocardium morphogenesis	IDA IDA: Inferred from direct assay	17336907	GOA
involved in wound healing	IDA IDA: Inferred from direct assay	12646923	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12646923	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	8702723	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	11389077	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16221846	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16221846	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pro-neuregulin-1, membrane-bound isoform

NRG1 class VII isoform alpha 2a	NRG1 class VII isoform alpha 2b
NRG1 class VII isoform alpha beta 2a	NRG1 class VII isoform alpha beta 3
NRG1 class VII isoform beta 2a	NRG1 class VII isoform beta 3
acetylcholine receptor-inducing activity	glial gro

Recombinant NRG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7365	NRG1-beta 1 Protein, Human	Q02297-6 (S177-E241)	≥95%
HY-P70524	NRG1-beta 1 Protein, Human (245a.a)	Q02297-6/AAA58639.1 (S2-K246)	≥95%
HY-P70967	NRG1-beta 1 Protein, Human (246a.a, His)	AAA58639.1 (M1-K246)	≥95%
HY-P72007	NRG1-beta 1 Protein, Human (65a.a, His)	Q02297-6 (S177-E241)	≥95%
HY-P73304	NRG1-beta 2 Protein, Human	Q02297-7 (S177-Q237)/E5RIG8 (S23-Q83)	≥95%
HY-P73325	NRG1-alpha Protein, Human (222a.a, HEK293, Fc)	Q02297-1 (S20-K241)	≥95%
HY-P73326	NRG1-alpha Protein, Human (HEK293, His)	Q02297-1 (S20-K241)	≥95%
HY-P73327	NRG1-alpha Protein, Human (65a.a, HEK293, Fc)	Q02297-1 (S177-K241)	≥95%
HY-P73328	NRG1-beta 1 Protein, Human (HEK293)	Q02297-6 (S2-K246)	≥95%
HY-P73329	NRG1-beta 1 Protein, Human (245a.a, HEK293, Fc)	Q02297-6 (S2-K246)	≥95%
HY-P73330	NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc)	Q02297-6 (T176-K246)	≥95%
HY-P73744	NRG1-beta 2 Protein, Human (HEK293, His)	Q02297-7/NP_001153480 (S20-K238)	≥95%
HY-P73745	NRG1-beta 2 Protein, Human (HEK293, Fc)	NP_001153480 (S177-Q237)	≥95%
HY-P71171A	NRG1-beta 1 Protein, Human (CHO)	Q02297-6 (T176-K246)	≥95%
HY-P700427	NRG1-beta 1 Protein, Human (HEK293, His)	Q02297-6 (S20-R247)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99268	Seribantumab		≥95.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168060	(8R)-8-Hydroxyepoxyboetirane A	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NRG1	NCBI
Mus musculus	NRG1	NCBI

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