ODC1 Protein, Human (His-T7)

ODC (ornithine decarboxylase) is the rate-limiting enzyme in polyamine biosynthesis, catalyzing the conversion of ornithine to putrescine, a precursor of polyamines such as spermidine and spermine, which influence cell proliferation and various cellular processes. ODC1 Protein, Human (His-T7) is the recombinant human-derived ODC1 protein, expressed by E. coli , with N-T7, C-6*His labeled tag. The total length of ODC1 Protein, Human (His-T7) is 461 a.a., with molecular weight of 25 & 58 kDa, respectively.

ODC (Ornithine Decarboxylase) is the rate-limiting enzyme in polyamine biosynthesis, and its activity is regulated by specific inhibitors, AZs (Antiaminoacidases), which in turn are inhibited by AZI (Antiaminoacidase Inhibitors). ODC1 catalyzes the first and rate-limiting step in polyamine biosynthesis, converting ornithine to putrescine, a precursor of polyamines such as spermidine and spermine. Polyamines are essential for cell proliferation and are involved in a variety of cellular processes ranging from DNA replication to apoptosis.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-T7;C-6*His

P11926 (M1-V461)

4953  [NCBI]

MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV

53 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 8% Trehalose, 2% Mannitol, 4 mM TCEP, 0.05% Tween 80, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.