OGN/Osteoglycin Protein, Human (HEK293, His)

OGN/osteoglycinin cooperates with TGF-β-1 or TGF-β-2 to play a crucial role in bone formation. Its synergistic interaction with these growth factors emphasizes its importance in regulating bone homeostasis and development. OGN/Osteoglycin Protein, Human (HEK293, His) is the recombinant human-derived OGN/Osteoglycin protein, expressed by HEK293 , with C-His labeled tag. The total length of OGN/Osteoglycin Protein, Human (HEK293, His) is 278 a.a., with molecular weight of 45-60 kDa.

OGN/Osteoglycin protein plays a crucial role in bone formation, collaborating with TGF-beta-1 or TGF-beta-2 to induce this process. Its functional synergy with these transforming growth factors underscores its significance in the regulation of bone homeostasis and development. By participating in the intricate signaling pathways involving TGF-beta isoforms, OGN contributes to the orchestration of molecular events that culminate in the formation and maintenance of bone tissue. The collaborative action of OGN with TGF-beta highlights its role as a modulator of bone formation processes, offering potential insights into the regulatory mechanisms underlying skeletal health and physiology.

Human

HEK293

C-His

P20774 (P21-F298)

4969  [NCBI]

PPTQQDSRIIYDYGTDNFEESIFSQDYEDKYLDGKNIKEKETVIIPNEKSLQLQKDEAITPLPPKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADIPNLRRLDFTGNLIEDIEDGTFSKLSLLEELSLAENQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKKLNNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGNPIVLGKHPNSFICLKRLPIGSYF

45-60 kDa

Greater than 95% as determined by reducing SDS-PAGE or Tris-Bis PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.