OGN - osteoglycin Gene

Homo sapiens

Also known as OG; OIF; SLRR3A

Gene ID: 4969 | Gene type: protein coding

About OGN

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:92,383,268-92,404,699 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues and 10 paralogues. Broad expression in gall bladder (RPKM 88.2), endometrium (RPKM 64.5) and 14 other tissues.

Summary

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

OGN Products(3)

mRNA	Protein	Name
NM_014057.5	NP_054776.1	mimecan isoform 2 precursor
NM_024416.4	NP_077727.3	mimecan isoform 1
NM_033014.4	NP_148935.1	mimecan isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OGN Protein Structure

LRR_8

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

mimecan

corneal keratan sulfate proteoglycan

OGN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OGN	P20774	CRK	Homo sapiens	P46108	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OGN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74664	OGN/Osteoglycin Protein, Human (HEK293, His)	P20774 (P21-F298)	≥95%

Related Diseases

Diseases

Alias

Inhibited Male Orgasm

Male Orgasmic Disorder

Psychosexual Dysfunction With Male Orgasmic Disorder

Adjustment Disorder

Adjustment Reaction	Adjustment Disorders
Adjustment Disease	Brief Situational Non-Psychotic Disorder
Adaptation Reaction Nos	Emotional Crisis
Situational Disorder	Situational Disturbance
Situational Maladjustment	Situational Reaction
Situational Reaction With Maladjustment	Transient Situational Disturbance

Combat Disorder

Combat Disorders

Combat Neurosis

Plantar Fascial Fibromatosis

Dupuytren'S Contracture Of Foot	Ledderhose'S Disease
Fibromatosis, Plantar	Ledderhose Disease

Post-Traumatic Stress Disorder

PTSD	Traumatic Neurosis
Post Traumatic Stress Disorder	Stress Disorders, Post-Traumatic
Posttraumatic Stress Disorder	Ptsd - [Post Traumatic Stress Disorder]
Trauma-Related Disorders

Dissociative Amnesia

Psychogenic Amnesia	Amnesia, Dissociative
Amnesia, Psychogenic	Amnesia Neurosis
Hysterical Fugue	Dissociative Fugue

Dissociative Disorder

Dissociative Disorders	Dissociative Disease
Dissociative Reaction

Psammomatous Meningioma

Acute Stress Disorder

Traumatic Stress Disorder	Stress Disorders, Traumatic, Acute
Stress Disorders, Traumatic

Macular Dystrophy, Corneal

Macular Corneal Dystrophy	MCD
Corneal Dystrophy, Macular Type	Groenouw Type Ii Corneal Dystrophy
Fehr Corneal Dystrophy	Macular Dystrophy, Corneal Type 1
Mcdc1	Macular Corneal Dystrophy Type Ii
Macular Corneal Dystrophy, Type Ii	Macular Corneal Dystrophy, Type I
Mcdc1, Formerly	Macular Dystrophy, Corneal, 1
Macular Corneal Dystrophy Type 1	Corneal Dystrophy Groenouw Type Ii
Corneal Dystrophy Macular Type	Macular Corneal Dystrophy Type I
Dystrophy, Macular, Corneal

Vaginal Cancer

Malignant Neoplasm Of Vagina	Vaginal Neoplasms
Malignant Tumor Of Vagina	Malignant Vaginal Tumor
Neoplasm Of Vagina	Vagina Neoplasm
Vaginal Tumor	Vaginal Carcinoma
Vaginal Malignant Epithelial Tumor	Vaginal Neoplasm
Malignant Vaginal Neoplasm	Vagina Carcinoma
Vaginal Neoplasia	Cancer Of Vagina
Malignant Tumour Of Vagina	Carcinoma Of Vagina
Primary Malignant Neoplasm Of Vagina	Vagina Wall Cancer
Vaginal Wall Cancer

Multiple Personality Disorder

Dissociative Identity Disorder

Multiple Personality

Cornea Plana

Flat Cornea

Amnestic Disorder

Amnesia	Amnestic Syndrome
Korsakoff'S Psychosis Or Syndrome	Amnesic Syndrome
Amnestic Disorder In Conditions Classified Elsewhere	Korsakoff Psychosis Or Syndrome, Nonalcoholic
Nonalcoholic Organic Amnesic Syndrome	Organic Amnesic Syndrome

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

Stromal Dystrophy

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09764	OGN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	OGN	VGNC	VGNC:44110
Rattus norvegicus	OGN	RGD	RGD:1308171
Felis catus	OGN	VGNC	VGNC:68622
Mus musculus	OGN	MGD	MGI:109278
Macaca mulatta	OGN	VGNC	VGNC:75582
Bos taurus	OGN	VGNC	VGNC:32414
Others	OGN	NCBI

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