PARM-1 Protein, Human (HEK293, His)

PARM-1 Protein is a highly glycosylated, mucin-like type 1 transmembrane protein primarily located at the plasma membrane and in the endocytic pathway. PARM-1 is also a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response, and its presence in most human tissues with especially high expression in heart, kidney and placenta. PARM-1 may regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. PARM-1 Protein, Human (HEK293, His) is the recombinant human-derived PARM-1 protein, expressed by HEK293 , with C-His labeled tag.

Prostate androgen-regulated mucin-like protein 1 (PARM-1) is a highly glycosylated, mucin-like type 1 transmembrane protein primarily located at the plasma membrane and in the endocytic pathway. PARM-1 is also a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response, and its presence in most human tissues with especially high expression in heart, kidney and placenta. PARM-1 contributes to ovulation and/or luteal function by acting as a novel regulator of progesterone metabolism. PARM-1 may regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. Moreover, ectopic expression of human PARM-1 in a prostate cancer cell line increases cell proliferation, thereby suggesting its role in the physiobiology of prostate and prostate cancer^{[1][2][13][4]}.

Human

HEK293

C-His

AAH13294.1 (L21-S258)

25849  [NCBI]

Approximately 25.7 kDa

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.