patZ Protein, E.coli

The patZ protein catalyzes the acetylation of lysine residues in a variety of target proteins, including RNase R and RNase II, during exponential phase. patZ Protein, E.coli is the recombinant E. coli-derived patZ protein, expressed by E. coli , with tag free. The total length of patZ Protein, E.coli is 885 a.a., .

patZ protein plays a pivotal role in cellular regulation through its acetyl-CoA-dependent acetylation of lysine residues on a diverse array of target proteins. Notably, it catalyzes the acetylation of RNase R and RNase II in exponential phase cells, impacting RNA metabolism. Additionally, patZ is essential for glucose-dependent acetylation on multiple lysines of alpha, beta, and beta' subunits of RNA polymerase (RNAP), influencing transcriptional processes. The acetyltransferase activity of patZ extends to key cellular components, including acetyl-coenzyme A synthetase (Acs) and the chromosomal replication initiator protein DnaA, leading to the inhibition of their functional activities. Furthermore, patZ overexpression results in widespread protein acetylation and hinders cellular motility. These findings underscore the multifaceted role of patZ in orchestrating diverse cellular processes through post-translational modifications.

E.coli

E. coli

Tag Free

P76594 (S2-S886)

947056

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.