Pentraxin 3/TSG-14 Protein, Human (HEK293, His)

RGS5 Protein is a protein that plays a crucial role in the regulation of G-protein coupled receptor signaling. It is involved in modulating cellular processes such as vasoconstriction and blood pressure regulation. Dysregulation of RGS5 Protein has been associated with various diseases, including hypertension and cardiovascular disorders. Targeting RGS5 Protein may offer potential therapeutic interventions in these conditions by restoring normal G-protein signaling and maintaining vascular homeostasis. Pentraxin 3/TSG-14 Protein, Human (HEK293, His) is the recombinant human-derived Pentraxin 3/TSG-14 protein, expressed by HEK293 , with C-10*His labeled tag and with natural variants A48D mutation. The total length of Pentraxin 3/TSG-14 Protein, Human (HEK293, His) is 364 a.a., with molecular weight of 44-50 kDa.

The Pentraxin 3/TSG-14 Protein, a member of the pentraxin protein family, is encoded by this gene. Its expression is induced by inflammatory cytokines in response to inflammatory stimuli, particularly in various mesenchymal and epithelial cell types, including endothelial cells and mononuclear phagocytes. This protein plays a crucial role in promoting fibrocyte differentiation and is actively involved in regulating inflammation and complement activation. Additionally, it contributes to angiogenesis and tissue remodeling. Notably, Pentraxin 3/TSG-14 serves as a biomarker for several inflammatory conditions, reflecting its potential clinical significance. The gene exhibits biased expression, with heightened levels in the bone marrow (RPKM 32.2), appendix (RPKM 24.8), and six other tissues, highlighting its specific involvement in various physiological contexts across multiple organs.

Immobilized Anti-TSG-14 at 1 μg/mL (100 μL/well) can bind TSG-14. The ED₅₀ for this effect is 0.04374 μg/mL.

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  Immobilized Anti-TSG-14 at 1 μg/mL (100 μL/well) can bind TSG-14 , The ED₅₀ for this effect is 0.04374 μg/mL.

Human

HEK293

C-10*His

NP_002843.2 (E18-S381, with natural variants A48D)

5806  [NCBI]

ENSDDYDLMYVNLDNEIDNGLHPTEDPTPCDCGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS

44-50 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.