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Pentraxin 3/TSG-14 Protein, Human (HEK293, His)

Cat. No.: HY-P73714
COA Handling Instructions

RGS5 Protein is a protein that plays a crucial role in the regulation of G-protein coupled receptor signaling. It is involved in modulating cellular processes such as vasoconstriction and blood pressure regulation. Dysregulation of RGS5 Protein has been associated with various diseases, including hypertension and cardiovascular disorders. Targeting RGS5 Protein may offer potential therapeutic interventions in these conditions by restoring normal G-protein signaling and maintaining vascular homeostasis. Pentraxin 3/TSG-14 Protein, Human (HEK293, His) is the recombinant human-derived Pentraxin 3/TSG-14 protein, expressed by HEK293 , with C-10*His labeled tag and with natural variants A48D mutation. The total length of Pentraxin 3/TSG-14 Protein, Human (HEK293, His) is 364 a.a., with molecular weight of 44-50 kDa.

For research use only. We do not sell to patients.

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2 μg $50 In-stock
10 μg $130 In-stock
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  • Biological Activity

  • Technical Parameters

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Description

RGS5 Protein is a protein that plays a crucial role in the regulation of G-protein coupled receptor signaling. It is involved in modulating cellular processes such as vasoconstriction and blood pressure regulation. Dysregulation of RGS5 Protein has been associated with various diseases, including hypertension and cardiovascular disorders. Targeting RGS5 Protein may offer potential therapeutic interventions in these conditions by restoring normal G-protein signaling and maintaining vascular homeostasis. Pentraxin 3/TSG-14 Protein, Human (HEK293, His) is the recombinant human-derived Pentraxin 3/TSG-14 protein, expressed by HEK293 , with C-10*His labeled tag and with natural variants A48D mutation. The total length of Pentraxin 3/TSG-14 Protein, Human (HEK293, His) is 364 a.a., with molecular weight of 44-50 kDa.

Background

The Pentraxin 3/TSG-14 Protein, a member of the pentraxin protein family, is encoded by this gene. Its expression is induced by inflammatory cytokines in response to inflammatory stimuli, particularly in various mesenchymal and epithelial cell types, including endothelial cells and mononuclear phagocytes. This protein plays a crucial role in promoting fibrocyte differentiation and is actively involved in regulating inflammation and complement activation. Additionally, it contributes to angiogenesis and tissue remodeling. Notably, Pentraxin 3/TSG-14 serves as a biomarker for several inflammatory conditions, reflecting its potential clinical significance. The gene exhibits biased expression, with heightened levels in the bone marrow (RPKM 32.2), appendix (RPKM 24.8), and six other tissues, highlighting its specific involvement in various physiological contexts across multiple organs.

Biological Activity

Immobilized Anti-TSG-14 at 1 μg/mL (100 μL/well) can bind TSG-14. The ED50 for this effect is 0.04374 μg/mL.

  • Immobilized Anti-TSG-14 at 1 μg/mL (100 μL/well) can bind TSG-14 , The ED50 for this effect is 0.04374 μg/mL.
Species

Human

Source

HEK293

Tag

C-10*His

Accession

NP_002843.2 (E18-S381, with natural variants A48D)

Gene ID
Molecular Construction
N-term
TSG-14 (E18-S381, A48D)
Accession # NP_002843.2
10*His
C-term
Synonyms
Pentraxin-related protein PTX3; TSG-14; PTX3; TNFAIP5; TSG14
AA Sequence

ENSDDYDLMYVNLDNEIDNGLHPTEDPTPCDCGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS

Molecular Weight

44-50 kDa

Purity
  • Greater than 95% as determined by reducing SDS-PAGE.
Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization or 20 mM PB, 150 mM NaCl, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Pentraxin 3/TSG-14 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Pentraxin 3/TSG-14 Protein, Human (HEK293, His)
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HY-P73714
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