PILR-alpha Protein, Human (HEK293)

Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing member of the paired receptor which consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction such as SH1 through dephosphorylation of signaling molecules. PILR-alpha Protein, Human (HEK293) is the recombinant human-derived PILR-alpha protein, expressed by HEK293 , with tag free.

Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing member of the paired receptor which consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules, while SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. PLPRA is a receptor for PIANP and also acts as an entry co-receptor for herpes simplex virus 1^[1][2][3].

Human

HEK293

Tag Free

AAH17812 (Q20-D226)

29992  [NCBI]

Approximately 33 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.