PILRA - paired immunoglobin like type 2 receptor alpha Gene

Homo sapiens

Also known as FDF03

Gene ID: 29992 | Gene type: protein coding

About PILRA

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,371,291-100,400,096 (from NCBI)

This gene has 7 transcripts (splice variants), 27 orthologues and 1 paralogue. Broad expression in appendix (RPKM 17.4), spleen (RPKM 11.8) and 23 other tissues.

Summary

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]

PILRA Products(3)

mRNA	Protein	Name
NM_013439.3	NP_038467.2	paired immunoglobulin-like type 2 receptor alpha isoform 1 precursor
NM_178272.2	NP_840056.1	paired immunoglobulin-like type 2 receptor alpha isoform 2 precursor
NM_178273.2	NP_840057.1	paired immunoglobulin-like type 2 receptor alpha isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10660620	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	10903717	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PILRA Protein Structure

V-set

0
100
200
303 a.a.

Protein Preferred Names

Protein Names

paired immunoglobulin-like type 2 receptor alpha

cell surface receptor FDF03

PILRA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PILRA	Q9UKJ1	NPDC1	Homo sapiens	Q9NQX5	SPR	30388101
Intra	PILRA	Q9UKJ1	NPDC1	Homo sapiens	Q9NQX5	FACS	30388101
Intra	PILRA	Q9UKJ1	PTPN6	Homo sapiens	P29350	Anti Tag CoIP	10660620
Intra	PILRA	Q9UKJ1	PTPN6	Homo sapiens	P29350	SPR	10660620
Cross	PILRA	Q9UKJ1	gB	Human herpesvirus 1	P06436	Anti Bait CoIP	18358807
Cross	PILRA	Q9UKJ1	gB	Human herpesvirus 1	P06436	FACS	18358807

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PILRA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77140	PILR-alpha Protein, Human (HEK293)	AAH17812 (Q20-D226)	≥95%
HY-P77141	PILR-alpha Protein, Human (HEK293, Fc)	AAH17812 (Q20-D226)	≥95%
HY-P77142	PILR-alpha Protein, Human (178a.a, HEK293, His)	Q9UKJ1-1 (Q20-A197)	≥95%
HY-P78022	PILR-alpha Protein, Human (178a.a, HEK293, Fc)	Q9UKJ1-1 (Q20-A197)	≥95%

Related Diseases

Diseases

Alias

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Inflammatory Bowel Disease 25

Early Onset Autosomal Recessive Inflammatory Bowel Disease 25	Ibd25
Inflammatory Bowel Disease 25, Autosomal Recessive

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10545	PILRA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PILRA	RGD	RGD:6497409
Mus musculus	PILRA	MGD	MGI:2450529
Others	PILRA	NCBI

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