PSMP Protein, Human (HEK293, Fc)

PSMP Protein acts as a ligand for CCR2, inducing chemotaxis and calcium mobilization. It attracts monocytes and lymphocytes, not neutrophils. It contributes to neuropathic pain and enhances synaptic transmission in dopamine neurons. PSMP Protein exists as a monomer or homodimer, binding to endothelial cells via proteoglycans. It interacts with TNFAIP6. PSMP Protein, Human (HEK293, Fc) is the recombinant human-derived PSMP protein, expressed by HEK293, with C-hFc labeled tag. The total length of PSMP Protein, Human (HEK293, Fc) is 103 a.a., with molecular weight of 45-50 kDa.

PSMP Protein acts as a ligand for C-C chemokine receptor CCR2, leading to the activation and binding of CCR2 and subsequently inducing a strong chemotactic response and mobilization of intracellular calcium ions. It displays chemotactic activity specifically for monocytes and lymphocytes, but not for neutrophils. Additionally, PSMP Protein plays a crucial role in mediating neuropathic pain resulting from peripheral nerve injury. It enhances NMDA-mediated synaptic transmission in dopamine D1 and D2 receptor-containing neurons, potentially through MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. PSMP Protein exists as a monomer or homodimer, with its presence on endothelial cells facilitated by glycosaminoglycan (GAG) side chains of proteoglycans. Furthermore, it interacts with TNFAIP6 through its Link domain.

Human

HEK293

C-hFc

Q1L6U9 (K37-S139)

692094  [NCBI]

45-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.