Serpin B4 Protein, Human (sf9, His)

Serpin B4 is a protease inhibitor that may modulate the host immune response against tumor cells, suggesting a crucial role in fine-tuning immune balance. Its ability to inhibit proteases emphasizes its importance in influencing key regulatory pathways, enhancing the immune system's effectiveness against cancer cells. Serpin B4 Protein, Human (sf9, His) is the recombinant human-derived Serpin B4 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Serpin B4 Protein, Human (sf9, His) is 390 a.a., with molecular weight of ~45 kDa.

The Serpin B4 protein emerges as a potential regulator in the host immune response against tumor cells by acting as a protease inhibitor. Its role as a modulator suggests a crucial function in fine-tuning the intricate balance of immune responses, particularly in the context of combating tumor cells. The protein's ability to inhibit proteases signifies its capacity to influence key regulatory pathways, potentially enhancing the immune system's effectiveness in recognizing and responding to cancerous cells. Serpin B4, in acting as a protease inhibitor, underscores its significance in the dynamic interplay between the immune system and tumor cells, positioning it as a promising candidate for further exploration in cancer immunotherapy.

Human

Sf9 insect cells

N-His

P48594 (M1-P390)

6318  [NCBI]

Approximately 45 kDa

Greater than 88% as determined by reducing SDS-PAGE

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 20% Glycerol, 1 mM EDTA, 1 mM DTT. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.