SERPINB4 - serpin family B member 4 Gene

Homo sapiens

Also known as PI11; SCCA1; SCCA2; LEUPIN; SCCA-2

Gene ID: 6318 | Gene type: protein coding

About SERPINB4

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,637,259-63,644,256 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 36 paralogues. Biased expression in esophagus (RPKM 63.1), urinary bladder (RPKM 11.6) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the serpin family of serine Protease Inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an Enzyme that kills tumor cells. This protein, along with Serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]

SERPINB4 Products(2)

mRNA	Protein	Name
NM_002974.4	NP_002965.1	serpin B4 isoform 1
NM_175041.2	NP_778206.1	serpin B4 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	21857942	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	21857942	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of peptidase activity	IDA IDA: Inferred from direct assay	12949073	GOA
involved in protection from natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	21857942	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINB4 Protein Structure

Serpin

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

serpin B4

SCCA2/SCCA1 fusion protein

SERPINB4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SERPINB4	P48594	SERPINB3	Homo sapiens	P29508	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINB4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77198	Serpin B4 Protein, Human (sf9, His)	P48594 (M1-P390)	≥95%

Related Diseases

Diseases

Alias

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Maxillary Sinus Inverted Papilloma

Inverted Papilloma Of The Maxillary Sinus

Maxillary Sinus Benign Neoplasm

Neoplasm Of Maxillary Sinus	Tumor Of Maxillofacial Sinus
Maxillary Sinus Neoplasms	Maxillary Sinus Neoplasm

Psoriasis

Acute Frontal Sinusitis

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Childhood Central Nervous System Primitive Neuroectodermal Neoplasm

Pediatric Cns Pnet

Childhood Central Nervous System Primitive Neuroectodermal Tumor

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12712	SERPINB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SERPINB4	RGD	RGD:1562868

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