SFRP4 Protein, Human (CHO, His)

The SFRP4 protein is a member of the soluble Frizzled-related protein (sFRP) and regulates Wnt signaling by directly interacting with Wnt. It has similar functions to other sFRPs and contributes to the regulation of cell growth and differentiation in specific cell types. SFRP4 Protein, Human (CHO, His) is the recombinant human-derived SFRP4 protein, expressed by CHO , with C-His labeled tag. The total length of SFRP4 Protein, Human (CHO, His) is 329 a.a., with molecular weight of ~39 kDa.

SFRP4, a member of the soluble frizzled-related proteins (sFRPs), serves as a modulator of Wnt signaling through its direct interaction with Wnts. Demonstrating functional similarities to other sFRPs, SFRP4 contributes to the regulation of cell growth and differentiation in specific cell types. Notably, it plays a crucial role in bone morphogenesis and may act as a regulator of adult uterine morphology and function. Additionally, SFRP4 is implicated in increasing apoptosis during ovulation, potentially through the modulation of FZ1/FZ4/WNT4 signaling. Furthermore, it exhibits phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. These diverse functions underscore the versatile regulatory role of SFRP4 in various cellular processes and physiological contexts.

Measured by its ability to inhibit Wnt3a-induced alkaline phosphatase production by C3H10T 1/2 2A6 mouse embryonal fibroblast cells. The ED₅₀ for this effect is typically 2-20 μg/mL in the presence of 20 ng/mL of Wnt3a.

Human

CHO

C-His

Q6FHJ7 (A22-V346)

6424  [NCBI]

Approximately 39 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.