SLC16A2 Protein, Human (Sf9, His, MBP, FLAG)

The SLC16A2 protein is a specific thyroid hormone transmembrane transporter that promotes bidirectional movement of thyroid hormone across cell membranes independent of pH or Na(+) gradients. SLC16A2 has a significant preference for substrates such as T3 and T4 and is a key mediator of thyroid hormone transport. SLC16A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC16A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC16A2 Protein, Human (Sf9, His, MBP, FLAG) is 538 a.a., .

SLC16A2, a specific thyroid hormone transmembrane transporter, plays a pivotal role in facilitating the uptake and efflux of thyroid hormones across the cell membrane, operating independently of pH or a Na(+) gradient. With a notable preference for substrates such as the iodothyronines T3 and T4, and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2), SLC16A2 emerges as a key mediator of thyroid hormone transport. Its significance is particularly pronounced in the transport of T3, notably through the blood-brain barrier, emphasizing its crucial role in enabling the entry of thyroid hormones into the brain. The transporter's ability to translocate thyroid hormones underscores its importance in regulating the cellular availability of these essential molecules, highlighting its impact on thyroid hormone homeostasis and its potential therapeutic relevance in various physiological contexts.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

P36021 (A2-I539)

6567

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.