TCTP/TPT1 Protein, Human (His)

TCTP/TPT1 is a multifunctional protein that plays a crucial role in cellular processes by participating in calcium binding and contributing to microtubule stabilization. As a negative regulator, it destabilizes TSC22D1, thereby inhibiting apoptosis. TCTP/TPT1 Protein, Human (His) is the recombinant human-derived TCTP/TPT1 protein, expressed by E. coli , with N-His labeled tag. The total length of TCTP/TPT1 Protein, Human (His) is 172 a.a., with molecular weight of ~23 kDa.

TCTP/TPT1, a multifaceted protein, assumes a crucial role in diverse cellular processes. It engages in calcium binding and contributes to microtubule stabilization, indicating its significance in maintaining cellular structure and function. Moreover, TCTP/TPT1 acts as a negative regulator of TSC22D1-mediated apoptosis by interacting with and destabilizing the TSC22D1 protein. The protein forms homodimers and interacts with STEAP3, suggesting its involvement in various protein-protein interactions that orchestrate cellular pathways. The interaction with TSC22D1 highlights its role in modulating apoptotic processes, emphasizing the multifunctional nature of TCTP/TPT1 in cellular homeostasis.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-His

P13693 (M1-C172)

7178  [NCBI]

MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKC

Approximately 23 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.