2. Gene
  3. TPT1 - tumor protein, translationally-controlled 1 Gene

TPT1 - tumor protein, translationally-controlled 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HRF; p02; p23; TCTP

Gene ID: 7178 | Gene type: protein coding

About TPT1

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:45,333,471-45,341,183 (from NCBI)

This gene has 14 transcripts (splice variants) and 247 orthologues. Ubiquitous expression in ovary (RPKM 496.6), thyroid (RPKM 416.5) and 25 other tissues.

Summary

This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including Apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some Cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

TPT1 Products(3)

mRNA Protein Name
NM_001286272.2 NP_001273201.1 translationally-controlled tumor protein isoform 1
NM_001286273.2 NP_001273202.1 translationally-controlled tumor protein isoform 3
NM_003295.4 NP_003286.1 translationally-controlled tumor protein isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
15162379 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16730713 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
11598139 GOA
involved in response to virus IEP
IEP: Inferred from expression pattern
16548883 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15162379 GOA
located in cytoplasmic microtubule IDA
IDA: Inferred from direct assay
15162379 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
15319436 GOA
located in multivesicular body IDA
IDA: Inferred from direct assay
15319436 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11598139 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
15162379 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPT1 Protein Structure

TCTP

TCTP: Translationally controlled tumour protein (1 - 168)

  • 0
  • 100
  • 172 a.a.
Protein Preferred Names Protein Names

translationally-controlled tumor protein

fortilin

TPT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TPT1 P13693 TUBA1C Homo sapiens Q9BQE3
Anti Bait CoIP
27607350
Intra
TPT1 P13693 TUBA1C Homo sapiens Q9BQE3
BiFC
27607350
Intra
TPT1 P13693 PRDX1 Homo sapiens Q06830
BiFC
27607350
Intra
TPT1 P13693 PRDX1 Homo sapiens Q06830
Anti Bait CoIP
27607350
Intra
TPT1 P13693 XRCC6 Homo sapiens P12956
BiFC
27607350
Intra
TPT1 P13693 XRCC6 Homo sapiens P12956
Anti Bait CoIP
22451927
Intra
TPT1 P13693 XRCC6 Homo sapiens P12956
Anti Bait CoIP
27607350
Intra
TPT1 P13693 ACTB Homo sapiens P60709
Anti Bait CoIP
27607350
Intra
TPT1 P13693 ACTB Homo sapiens P60709
BiFC
27607350
Intra
TPT1 P13693 YBX1 Homo sapiens P67809
Anti Bait CoIP
27607350
Intra
TPT1 P13693 YBX1 Homo sapiens P67809
BiFC
27607350
Intra
TPT1 P13693 HSPA9 Homo sapiens P38646
BiFC
27607350
Intra
TPT1 P13693 HSPA9 Homo sapiens P38646
Anti Bait CoIP
27607350
Intra
TPT1 P13693 XRCC5 Homo sapiens P13010
Anti Bait CoIP
22451927
Intra
TPT1 P13693 EEF1D Homo sapiens P29692
Y2H Array
25416956
Intra
TPT1 P13693 EEF1D Homo sapiens P29692
Y2H Prey Pooling
25416956
Intra
TPT1 P13693 TRIP13 Homo sapiens Q15645
Y2H Array
25416956
Intra
TPT1 P13693 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
25416956
Intra
TPT1 P13693 TP53 Homo sapiens P04637
Anti Bait CoIP
21081126
Intra
TPT1 P13693 TP53 Homo sapiens P04637
Anti Tag CoIP
21081126
Intra
TPT1 P13693 TP53 Homo sapiens P04637
Anti Bait CoIP
22451927
Intra
TPT1 P13693 EEF1D Homo sapiens P29692-2
Y2H Array
25416956
Intra
TPT1 P13693 TSC22D1 Homo sapiens Q15714
Anti Bait CoIP
18325344
Intra
TPT1 P13693 TSC22D1 Homo sapiens Q15714
Y2H
18325344
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TPT1 Proteins

Cat. No. Product Name Accession Purity
HY-P77224 TCTP/TPT1 Protein, Human (His) P13693 (M1-C172) ≥95%
HY-P700615 TCTP/TPT1 Protein, Human P13693 (M1-C172) ≥95%
HY-P700623 TCTP/TPT1 Protein, Human (HEK293, His) P13693 (M1-C172) ≥95%

Related Diseases

Diseases Alias
Chronic Urticaria

Urticaria Chronic

Chronic Spontaneous Urticaria

Chronic Ordinary Urticaria
Drug Allergy

Allergy Drug

Drug Allergies
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Allergic Rhinitis

Hay Fever

Allergic Rhinitis, Susceptibility To

ALRH

Atopic Rhinitis

Seasonal Allergic Rhinitis

Non-Seasonal Allergic Rhinitis

Perenial Allergic Rhinitis

Pollenosis

Rhinitis Allergic Seasonal

Rhinitis, Allergic, Perennial

Allergic Rhinitis, Cause Unspecified

Pollinosis

Pollen Allergy

Allergy Nos Due To Pollen

Summer Catarrh

Other Seasonal Allergic Rhinitis
Rhinitis

Runny Nose
Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Paraneoplastic Cerebellar Degeneration

Pcd

Paraneoplastic Cerebellar Ataxia

Rapidely Progressive Cerebellar Syndrome

Subacute Cerebellar Degeneration
Mycetoma

Madura Foot

Mycetoma Of Foot
Epithelial-Stromal Tgfbi Dystrophy
Eumycotic Mycetoma

Eumycetoma

Maduromycosis

Mycetoma

Madura Foot

Maduromycosis, Mycotic

Mycotic Mycetoma

Mycetoma Of Foot

Eumycotic Maduromycosis

Mycetoma Due To Fungal Infection
Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria
Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V
Food Allergy

Food Hypersensitivity

Food Allergies

Allergy Food

Food Allergen-Induced Hypersensitivity
Trichothiodystrophy 7, Nonphotosensitive

TTD7

Nonphotosensitive Trichothiodystrophy 7

Trichothiodystrophy 7, Non-Photosensitive
Pericarditis
Diabetic Macular Edema
Dermatomycosis

Dermatomycoses
Retinal Vascular Occlusion

Retinal Vasc. Occlusion

Occlusion Of Retinal Vessels

Retinal Obstruction
Retinal Artery Occlusion

Retina Artery Narrowing

Retinal Artery Spasm

Spasm Of Ophthalmic Artery

Retinal Spasm

Vasospasm Of Retina
Macular Retinal Edema

Macular Edema

Macular Oedema

Macular Retinal Oedema

Macular Edema, Cystoid
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14956 TPT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TPT1 MGD MGI:104890
Rattus norvegicus TPT1 RGD RGD:621623
Felis catus TPT1 VGNC VGNC:102352