TGFBR3/TGF-beta RIII Protein, Human (sf9, His)

TGFBR3/TGF-beta RIII Protein is pivotal, binding to TGF-beta, indicating a potential role in capturing and presenting TGF-beta to signaling receptors. In gonadotrope cells, it acts as an inhibin A coreceptor, regulating FSH levels and impacting female fertility. Its interaction with DYNLT4 emphasizes diverse functional associations in cellular processes, suggesting a multifaceted role for TGFBR3 in cellular regulation and fertility control. TGFBR3/TGF-beta RIII Protein, Human (sf9, His) is the recombinant human-derived TGFBR3/TGF-beta RIII protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TGFBR3/TGF-beta RIII Protein, Human (sf9, His) is 761 a.a., with molecular weight of ~88 kDa.

The TGFBR3/TGF-beta RIII protein plays a pivotal role as it binds to TGF-beta, suggesting potential involvement in capturing and retaining TGF-beta for presentation to the signaling receptors, as inferred by similarity to related proteins. Particularly in gonadotrope cells, TGFBR3 acts as an inhibin A coreceptor, exerting regulatory control over follicle-stimulating hormone (FSH) levels and influencing female fertility, as indicated in relevant studies. Furthermore, TGFBR3 interacts with DYNLT4, underscoring its diverse functional associations in cellular processes.

Human

Sf9 insect cells

C-His

Q03167 (G21-G781)

7049  [NCBI]

Approximately 88 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.