Tubby Protein, Human (His)

Tubby, implicated in G protein-coupled receptor signaling, binds phosphatidylinositol 4,5-bisphosphate on membranes and may play a role in nuclear transcription regulation. Potentially involved in hypothalamic weight regulation and contributes to phagocytosis of apoptotic cells. Interacts with GNAQ and TULP1. Tubby Protein, Human (His) is the recombinant human-derived Tubby protein, expressed by E. coli , with N-His labeled tag. The total length of Tubby Protein, Human (His) is 506 a.a., with molecular weight of 56.74 kDa.

Tubby protein operates in signal transduction pathways initiated by heterotrimeric G protein-coupled receptors, demonstrating an affinity for membranes containing phosphatidylinositol 4,5-bisphosphate. Additionally, Tubby protein exhibits DNA-binding capability in vitro and may play a role in transcriptional regulation within the nucleus. Implications for its involvement in the hypothalamic control of body weight are suggested. Furthermore, Tubby protein contributes to the stimulation of phagocytosis, particularly in apoptotic retinal pigment epithelium (RPE) cells and macrophages. Its interactions with GNAQ and TULP1 underscore its multifaceted role in cellular processes.

Human

E. coli

N-His

P50607-1 (M1-E506)

/

56.74 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.