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Tubby Protein, Human (His)

Cat. No.: HY-P701073
Handling Instructions

Tubby, implicated in G protein-coupled receptor signaling, binds phosphatidylinositol 4,5-bisphosphate on membranes and may play a role in nuclear transcription regulation. Potentially involved in hypothalamic weight regulation and contributes to phagocytosis of apoptotic cells. Interacts with GNAQ and TULP1. Tubby Protein, Human (His) is the recombinant human-derived Tubby protein, expressed by E. coli , with N-His labeled tag. The total length of Tubby Protein, Human (His) is 506 a.a., with molecular weight of 56.74 kDa.

For research use only. We do not sell to patients.

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Description

Tubby, implicated in G protein-coupled receptor signaling, binds phosphatidylinositol 4,5-bisphosphate on membranes and may play a role in nuclear transcription regulation. Potentially involved in hypothalamic weight regulation and contributes to phagocytosis of apoptotic cells. Interacts with GNAQ and TULP1. Tubby Protein, Human (His) is the recombinant human-derived Tubby protein, expressed by E. coli , with N-His labeled tag. The total length of Tubby Protein, Human (His) is 506 a.a., with molecular weight of 56.74 kDa.

Background

Tubby protein operates in signal transduction pathways initiated by heterotrimeric G protein-coupled receptors, demonstrating an affinity for membranes containing phosphatidylinositol 4,5-bisphosphate. Additionally, Tubby protein exhibits DNA-binding capability in vitro and may play a role in transcriptional regulation within the nucleus. Implications for its involvement in the hypothalamic control of body weight are suggested. Furthermore, Tubby protein contributes to the stimulation of phagocytosis, particularly in apoptotic retinal pigment epithelium (RPE) cells and macrophages. Its interactions with GNAQ and TULP1 underscore its multifaceted role in cellular processes.

Species

Human

Source

E. coli

Tag

N-His

Accession

P50607-1 (M1-E506)

Gene ID

/

Molecular Construction
N-term
His
Tubby (M1-E506)
Accession # P50607-1
C-term
Synonyms
Tubby protein homolog; TUB; RD5; RDOB
Molecular Weight

56.74 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Tubby Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Tubby Protein, Human (His)
Cat. No.:
HY-P701073
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