uPAR Protein, Human (Domain 1, HEK293, His)

uPAR Protein, a receptor for urokinase plasminogen activator, actively localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction activated by U-PA and undergoes negative-feedback regulation. As a monomer, it interacts with MRC2, SRPX2, and FAP at invadopodia. Engaging SORL1, it forms a ternary complex with PLAUR, PLAU, and SERPINE1, influencing PLAUR internalization. The interaction with SORL1 occurs via the N-terminal ectodomain, highlighting uPAR's multifaceted role in cellular functions. uPAR Protein, Human (Domain 1, HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Human (Domain 1, HEK293, His) is 92 a.a., with molecular weight of 17-25 kDa.

uPAR Protein functions as a receptor for urokinase plasminogen activator, actively participating in the localization and facilitation of plasmin formation. Additionally, it serves as a mediator of the proteolysis-independent signal transduction activation effects induced by U-PA. Subject to negative-feedback regulation by U-PA, uPAR Protein undergoes cleavage into an inactive form. Typically existing as a monomer, it interacts with various proteins, including MRC2, SRPX2 (via the UPAR/Ly6 domains), and FAP (seprase), with the latter interaction occurring at the cell surface of invadopodia membrane. Moreover, uPAR Protein engages in an interaction with SORL1, specifically through the N-terminal ectodomain, and this interaction has been associated with a decrease in PLAUR internalization. Notably, the formation of a ternary complex composed of PLAUR, PLAU (urokinase-type plasminogen activator), and SERPINE1 also involves an interaction with SORL1.

Human

HEK293

C-His

Q03405-1 (L23-Y114)

5329  [NCBI]

17-25 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.